Description

2-Methylcrotonic Acid Trimethylsilyl Ester is a specialized organosilicon reagent widely used as a versatile building block in advanced organic synthesis. This compound is valued for its role in introducing the trimethylsilyl (TMS) protecting group and as a reactive intermediate in the synthesis of complex molecules. It is primarily utilized by research institutions and industrial R&D departments in the pharmaceutical, agrochemical, and material science sectors for developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for introducing sterically hindered acid functionalities.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and plant growth regulators requiring specific carboxylic acid derivatives.
• Organosilicon Chemistry: Serves as a precursor for more complex silanes and silicone-based polymers with tailored properties.
• Material Science Research: Employed in the development of novel organic-inorganic hybrid materials and surface modification agents.
• Protecting Group Strategy: The trimethylsilyl ester acts as a protecting group for carboxylic acids during multi-step synthetic sequences.
• Cross-Coupling Reactions: Utilized as a substrate in various metal-catalyzed cross-coupling reactions to form new carbon-carbon bonds.

Basic Information

Product Name	2-Methylcrotonic Acid Trimethylsilyl Ester
CAS No.	55517-33-4
Molecular Formula	C8H16O2Si
Molecular Weight	172.30 g/mol
Synonyms	Trimethylsilyl 2-methylbut-2-enoate; 2-Butenoic acid, 2-methyl-, trimethylsilyl ester; 2-Methyl-2-butenoic acid trimethylsilyl ester; TMS ester of 2-methylcrotonic acid; Tiglic acid trimethylsilyl ester; Trimethylsilyl tiglate; (E)-2-Methyl-2-butenoic acid trimethylsilyl ester; 3-Methylcrotonic acid trimethylsilyl ester (common misnomer)
EINECS	Contact for details

Quality Control

Our 2-Methylcrotonic Acid Trimethylsilyl Ester is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including chromatography (GC/HPLC) and spectroscopic methods (NMR, IR), to ensure high chemical purity and identity. Certificates of Analysis (COA) documenting purity, assay, and impurity profiles are available for every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic and highly volatile nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition. Keep away from heat, sparks, and open flames.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.