Description

Glutaric Acid Bis(Trimethylsilyl) Ester is a high-purity silylating reagent and versatile synthetic intermediate used for the protection of carboxylic acid groups. This compound is valued for its ability to enhance the volatility and stability of target molecules, facilitating advanced analytical and synthetic processes. It is primarily required by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for the synthesis of complex organic molecules and analytical derivatization.

Application

• Derivatization Agent for GC/MS Analysis: Used to silylate carboxylic acids, improving their thermal stability and volatility for accurate gas chromatography-mass spectrometry characterization.
• Carboxylic Acid Protection in Organic Synthesis: Serves as a key protecting group reagent in multi-step synthetic routes for pharmaceuticals and fine chemicals, enabling selective reactions.
• Intermediate for Silicon-Containing Compounds: Acts as a building block in the synthesis of specialized siloxanes and other organosilicon materials.
• Polymer Modification: Employed in the functionalization of polymer chains to introduce trimethylsilyl groups, altering material properties like hydrophobicity.
• Metabolite Analysis: Facilitates the detection and quantification of acidic metabolites in bioanalytical studies through efficient derivatization.
• Reagent for Peptide Chemistry: Used in the temporary protection of side-chain carboxyl groups during peptide synthesis.

Basic Information

Product Name	Glutaric Acid Bis(Trimethylsilyl) Ester
CAS No.	55494-07-0
Molecular Formula	C13H30O4Si2
Molecular Weight	306.55 g/mol
Synonyms	Bis(trimethylsilyl) glutarate; Glutaric Acid Bis(trimethylsilyl) Ester; Pentanedioic Acid Bis(trimethylsilyl) Ester; 1,5-Bis(trimethylsiloxy)-1,5-dioxopentane; Trimethylsilyl glutarate; Glutaric Acid Di(trimethylsilyl) Ester; TMS Glutarate
EINECS	Contact for details

Quality Control

Our Glutaric Acid Bis(Trimethylsilyl) Ester is manufactured under controlled conditions to ensure high chemical purity and lot-to-lot consistency. Each batch undergoes rigorous analytical testing, including assay by GC or HPLC and identity confirmation by IR and NMR spectroscopy. Certificates of Analysis (COA) detailing purity, impurity profile, and physical characteristics are provided to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.