Description

n-(3-Methyl-1-Oxobutyl)Glycine Trimethylsilyl Ester is a specialized organosilicon-protected amino acid derivative, primarily used as a key synthetic intermediate in advanced organic synthesis. Its value lies in providing a protected glycine moiety with a trimethylsilyl (TMS) group, which enhances solubility in organic solvents and facilitates specific coupling reactions. This compound is essential for researchers and manufacturers in the pharmaceutical and fine chemical industries, particularly for the development of peptides, peptidomimetics, and novel bioactive molecules.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of complex peptide-based drugs and active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to introduce modified glycine residues with specific side-chain protection.
• Proteomics Research: Serves as a reagent in chemical biology for labeling, cross-linking, or modifying proteins and peptides for study.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals, catalysts, and ligands for asymmetric synthesis.
• Agrochemical Development: Acts as an intermediate in creating novel herbicides, fungicides, or plant growth regulators with peptide-like structures.
• Material Science: Potential precursor for silicon-containing polymers or hybrid organic-inorganic materials.

Basic Information

Product Name	n-(3-Methyl-1-Oxobutyl)Glycine Trimethylsilyl Ester
CAS No.	55494-00-3
Molecular Formula	C11H23NO3Si
Molecular Weight	245.39 g/mol
Synonyms	N-(3-Methyl-1-oxobutyl)glycine trimethylsilyl ester; N-(3-Methylbutanoyl)glycine trimethylsilyl ester; N-(Isovaleryl)glycine TMS ester; Trimethylsilyl N-(3-methyl-1-oxobutyl)glycinate; Glycine, N-(3-methyl-1-oxobutyl)-, trimethylsilyl ester; Isovalerylglycine trimethylsilyl ester; TMS-isovalerylglycine
EINECS	Contact for details

Quality Control

Our n-(3-Methyl-1-Oxobutyl)Glycine Trimethylsilyl Ester is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and structural identity. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.