Description

2-(Methoxyimino)-3-Methylbutanoic Acid Trimethylsilyl Ester is a specialized organosilicon-protected intermediate of significant value in advanced organic synthesis. Its primary function is to serve as a key building block for the introduction of the methoxyimino group, a crucial structural motif in the development of active pharmaceutical ingredients (APIs) and agrochemicals. This compound is particularly sought after by R&D chemists and process development scientists in the pharmaceutical and crop protection industries for constructing complex molecules with high precision and yield.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly those requiring the methoxyimino functional group for bioactivity.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, where the trimethylsilyl ester group offers superior reactivity and selectivity.
• Peptide Mimetics & Modifications: Employed in medicinal chemistry for the modification of amino acids and the synthesis of peptide analogs to enhance metabolic stability.
• Cross-Coupling Reactions: Acts as a substrate in various metal-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) to form complex carbon-carbon bonds.
• Protecting Group Strategy: The trimethylsilyl (TMS) ester serves as a temporary protecting group for carboxylic acids during multi-step synthetic sequences.
• Chemical Research & Development: A valuable reagent for academic and industrial research laboratories exploring new synthetic methodologies and heterocyclic chemistry.

Basic Information

Product Name	2-(Methoxyimino)-3-Methylbutanoic Acid Trimethylsilyl Ester
CAS No.	55493-95-3
Molecular Formula	C9H19NO3Si
Molecular Weight	217.34 g/mol
Synonyms	Trimethylsilyl 2-(Methoxyimino)-3-methylbutanoate; 3-Methyl-2-(methoxyimino)butanoic Acid Trimethylsilyl Ester; TMS Ester of 2-Methoxyimino-3-methylbutyric Acid; (Trimethylsilyl) 3-methyl-2-(methoxyimino)butanoate; 2-Methoxyimino-3-methylbutyric Acid TMS Ester; O-Trimethylsilyl 2-(Methoxyimino)-3-methylbutyrate; 55493-95-3; Butanoic acid, 2-(methoxyimino)-3-methyl-, trimethylsilyl ester
EINECS	Contact for details

Quality Control

Our 2-(Methoxyimino)-3-Methylbutanoic Acid Trimethylsilyl Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for sensitive synthetic applications. Each lot is analyzed using advanced chromatographic and spectroscopic techniques (HPLC, GC, NMR). A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.