Description

(Methoxyimino)Acetic Acid Trimethylsilyl Ester is a versatile organosilicon reagent and a key protected intermediate in synthetic organic chemistry. Its primary value lies in its role as a reactive synthon for introducing the methoxyiminoacetate functional group, which is crucial for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for the synthesis of active ingredients and advanced intermediates.

Application

• Pharmaceutical Synthesis: A critical building block for the preparation of β-lactam antibiotics and other nitrogen-containing heterocycles.
• Agrochemical Intermediates: Used in the synthesis of fungicides and herbicides that require the methoxyiminoacetate moiety.
• Peptide Mimetics: Serves as a precursor for unnatural amino acids and peptide backbone modifications.
• Material Science Research: Employed as a silylating agent or as a monomer precursor for specialized polymers.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed reactions for carbon-carbon bond formation.
• Protecting Group Strategy: The trimethylsilyl (TMS) group provides temporary protection for carboxylic acids during multi-step syntheses.

Basic Information

Product Name	(Methoxyimino)Acetic Acid Trimethylsilyl Ester
CAS No.	55493-91-9
Molecular Formula	C8H17NO3Si
Molecular Weight	203.31 g/mol
Synonyms	Trimethylsilyl (methoxyimino)acetate; (Methoxyimino)acetic acid TMS ester; Acetic acid, (methoxyimino)-, trimethylsilyl ester; O-Trimethylsilyl (methoxyimino)acetate; (Methoxyimino)acetoxytrimethylsilane; TMS Methoxyiminoacetate; (Z)-(Methoxyimino)acetic Acid Trimethylsilyl Ester
EINECS	Contact for details

Quality Control

Our (Methoxyimino)Acetic Acid Trimethylsilyl Ester is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC/HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for research and industrial synthesis. Certificates of Analysis (COA) with full traceability are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent hydrolysis.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.