Description

N,o-Bis(Trifluoroacetyl)-3-Trifluoroacetyloxy-L-Tyrosine Butyl Ester is a highly functionalized, protected derivative of the amino acid L-tyrosine, designed for advanced synthetic applications. This compound matters as a critical chiral building block and key intermediate in the synthesis of complex peptides, radiopharmaceuticals, and other bioactive molecules where precise stereochemistry and functional group manipulation are paramount. It is primarily needed by research institutions and pharmaceutical development teams working on targeted drug discovery, particularly in oncology and neurology, as well as by fine chemical manufacturers producing high-value specialty compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of peptide-based drugs and targeted therapeutics.
• Radiopharmaceutical Precursor: Used in the development of Positron Emission Tomography (PET) tracers, where the trifluoroacetyl groups can be utilized for further fluorination or as protecting groups.
• Proteomics Research: Serves as a modified amino acid derivative in the study of protein structure, function, and post-translational modifications.
• Organic Synthesis Building Block: Employed in academic and industrial research for constructing complex organic molecules with specific stereocenters and protected functionalities.
• Peptide Chemistry: Acts as a protected tyrosine derivative in solid-phase and solution-phase peptide synthesis (SPPS) to prevent side reactions.
• Bioconjugation Agent: Potential use in creating labeled biomolecules for diagnostic assays and imaging studies.

Basic Information

Product Name	N,o-Bis(Trifluoroacetyl)-3-Trifluoroacetyloxy-L-Tyrosine Butyl Ester
CAS No.	55493-76-0
Molecular Formula	C₂₁H₂₁F₉N₁O₇
Molecular Weight	588.39 g/mol
Synonyms	L-Tyrosine, N,o-bis(trifluoroacetyl)-3-(trifluoroacetyloxy)-, butyl ester; Butyl N,o-bis(trifluoroacetyl)-3-trifluoroacetyloxy-L-tyrosinate; N,O-Bis(trifluoroacetyl)-O3-(trifluoroacetyl)-L-tyrosine butyl ester; 3-Trifluoroacetyloxy-L-tyrosine N,o-bis(trifluoroacetyl) butyl ester; Fmoc-Tyr(3-O-TFA)-OtBu (related protected form); Protected L-Tyrosine Butyl Ester
EINECS	Contact for details

Quality Control

Our N,o-Bis(Trifluoroacetyl)-3-Trifluoroacetyloxy-L-Tyrosine Butyl Ester is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification and impurity profiling, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed HPLC, NMR, and mass spectrometry data are provided to guarantee identity, purity, and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This compound is hygroscopic (moisture-sensitive); containers must be kept sealed under inert atmosphere (argon or nitrogen) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.