Description

6-β-Naloxol Hcl is a high-purity pharmaceutical intermediate and reference standard of significant importance in medicinal chemistry and analytical research. This compound serves as a key precursor in the synthesis and development of opioid receptor antagonists and related therapeutic agents. It is primarily utilized by research institutions, pharmaceutical development laboratories, and quality control departments for method development, impurity profiling, and pharmacological studies.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of advanced opioid antagonists and related active pharmaceutical ingredients (APIs).
• Analytical Reference Standard: Used in HPLC, GC-MS, and other chromatographic methods for the identification, assay, and impurity quantification of naloxone and related compounds.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to develop new therapeutics targeting opioid receptors.
• Quality Control & Assurance: Essential for pharmaceutical manufacturers to validate analytical methods and ensure batch-to-batch consistency of final drug products.
• Metabolite Studies: Used in pharmacokinetic and metabolic pathway research for opioid drugs.
• Regulatory Compliance: Supports regulatory filings by providing characterized materials for stability studies and impurity identification.

Basic Information

Product Name	6-β-Naloxol Hcl
CAS No.	55488-85-2
Molecular Formula	C20H24ClNO4
Molecular Weight	377.86 g/mol
Synonyms	6β-Naloxol Hydrochloride; 6β-Naloxol HCl; 17-Allyl-4,5α-epoxy-3,14-dihydroxymorphinan-6β-ol Hydrochloride; Noroxymorphone-6β-ol Hydrochloride; 6β-Hydroxynaloxone Hydrochloride; (5α,6β)-17-Allyl-4,5-epoxy-3,14-dihydroxymorphinan-6-ol Hydrochloride
EINECS	Contact for details

Quality Control

Our 6-β-Naloxol Hcl is manufactured under strict quality management systems to ensure the highest standards of purity and consistency. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and stringent controls for residual solvents and related substances. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, detailing all test results against established specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.