Description

Pentafluorophenyldimethylsilyldiethylamine is a specialized organosilicon reagent featuring a pentafluorophenyl group and a silylated amine moiety. This compound is valued for its role as a versatile protecting group and activating agent in advanced organic synthesis, particularly for sensitive substrates. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate Synthesis: Employed as a protecting group for amines and alcohols in the multi-step synthesis of active pharmaceutical ingredients (APIs).
• Peptide Chemistry: Used to activate carboxylic acids or protect functional groups during solid-phase and solution-phase peptide synthesis.
• Agrochemical Research: Serves as a key building block in the development of novel herbicides, fungicides, and insecticides.
• Material Science: Acts as a precursor or surface modifying agent in the creation of specialty silicones and fluorinated polymers.
• Cross-Coupling Reactions: Facilitates palladium-catalyzed reactions as a silyl transfer agent or as a precursor to reactive intermediates.
• Analytical Derivatization: Used to derivative compounds for gas chromatography (GC) or mass spectrometry (MS) analysis to improve volatility or detection.

Basic Information

Product Name	Pentafluorophenyldimethylsilyldiethylamine
CAS No.	55485-74-0
Molecular Formula	C12H16F5NSi
Molecular Weight	297.34 g/mol
Synonyms	Diethyl(2,3,4,5,6-pentafluorophenyl)dimethylsilylamine; N,N-Diethyl-1,1-dimethyl-1-(pentafluorophenyl)silanamine; Pentafluorophenyldimethylsilyl diethylamine; (Diethylamino)dimethyl(pentafluorophenyl)silane; Dimethyl(pentafluorophenyl)(diethylamino)silane; PFP-DMS-DEA; Silane, (diethylamino)dimethyl(2,3,4,5,6-pentafluorophenyl)-
EINECS	Contact for details

Quality Control

Our Pentafluorophenyldimethylsilyldiethylamine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including NMR, HPLC, and GC analysis to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, containers should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (NMR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.