Description

N,N,1-Tris(Trimethylsilyl)-5-[(Trimethylsilyl)Oxy]-1H-Indole-3-Ethanamine CAS NO 55429-74-8 is a highly functionalized, multi-silylated indole derivative, a key advanced intermediate in complex organic synthesis. Its value lies in its role as a versatile, protected building block for constructing sophisticated nitrogen-containing heterocycles, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists working on novel active pharmaceutical ingredients (APIs), agrochemicals, and specialty fine chemicals.

Application

• Pharmaceutical Intermediate: A critical protected synthon for the synthesis of complex indole-based drug candidates, including potential serotonin receptor modulators and kinase inhibitors.
• Agrochemical Research: Used in the development of novel pesticides and herbicides where the indole scaffold provides unique biological activity.
• Material Science Precursor: Serves as a starting material for creating specialized silicon-containing polymers or organic semiconductors.
• Academic & R&D Laboratories: Employed in methodological studies and the total synthesis of natural products featuring intricate indole architectures.
• Process Chemistry: Utilized in route scouting and scale-up optimization for the commercial production of high-value specialty chemicals.

Basic Information

Product Name	N,N,1-Tris(Trimethylsilyl)-5-[(Trimethylsilyl)Oxy]-1H-Indole-3-Ethanamine
CAS No.	55429-74-8
Molecular Formula	C23H48N2O1Si4
Molecular Weight	481.0 g/mol
Synonyms	1H-Indole-3-ethanamine, N,N,1-tris(trimethylsilyl)-5-[(trimethylsilyl)oxy]-; 5-(Trimethylsilyloxy)-N,N,1-tris(trimethylsilyl)-1H-indole-3-ethanamine; Tetrakis(trimethylsilyl) Protected Indole Amine; TMS-protected 5-hydroxyindole-3-ethylamine derivative; N,N,1-Tris(trimethylsilyl)-5-(trimethylsilyloxy)indole-3-ethylamine; 55429-74-8; Multi-silylated indole intermediate
EINECS	Contact for details

Quality Control

Our N,N,1-Tris(Trimethylsilyl)-5-[(Trimethylsilyl)Oxy]-1H-Indole-3-Ethanamine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical characterization, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with full traceability are provided with every shipment. We support cGMP compliance for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be handled under an inert atmosphere (argon or nitrogen) to prevent degradation. Keep away from heat and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.