Description

(S)-α-[[(Trimethylsilyl)Oxy]Methyl]Benzeneacetic Acid (1α,2β,4β,5α)-9-Methyl-3-Oxa-9-Azatricyclo[3.3.1.02,4]Nonan-7β-Yl Ester is a high-purity, advanced pharmaceutical intermediate characterized by its complex, stereochemically defined bicyclic structure. This compound is of critical importance for enabling the synthesis of sophisticated active pharmaceutical ingredients (APIs), particularly in the development of central nervous system (CNS) and analgesic drugs. It is primarily needed by research institutions, custom synthesis organizations, and pharmaceutical manufacturers engaged in process development and scale-up of novel therapeutics.

Application

• Key Intermediate in Pharmaceutical Synthesis: Serves as a crucial building block for the production of complex, stereospecific active pharmaceutical ingredients (APIs).
• Neurological Drug Development: Used in the research and manufacturing of potential therapeutics targeting the central nervous system.
• Analgesic Research: Applied in the synthesis pathway for novel pain management compounds.
• Process Chemistry & Scale-Up: Employed by process chemists for route scouting, optimization, and pilot-scale production.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific molecule production.
• Academic & Industrial Research: Utilized in medicinal chemistry programs for structure-activity relationship (SAR) studies and new chemical entity (NCE) discovery.

Basic Information

Product Name	(S)-α-[[(Trimethylsilyl)Oxy]Methyl]Benzeneacetic Acid (1α,2β,4β,5α)-9-Methyl-3-Oxa-9-Azatricyclo[3.3.1.02,4]Nonan-7β-Yl Ester
CAS No.	55373-83-6
Molecular Formula	C21H31NO4Si
Molecular Weight	389.57 g/mol
Synonyms	(S)-α-[[(Trimethylsilyl)oxy]methyl]benzeneacetic acid (1α,2β,4β,5α)-9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-7β-yl ester; 9-Methyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-7β-ol, α-[[(trimethylsilyl)oxy]methyl]benzenecetate, (1α,2β,4β,5α,7β)-, (αS)-; Tropanyl (S)-α-[[(trimethylsilyl)oxy]methyl]benzeneacetate; Tropic acid trimethylsilyl ether tropane ester; (S)-Tropic acid TMS ether tropane ester; 55373-83-6; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and reliability for critical pharmaceutical applications. Quality is verified through comprehensive analytical techniques including HPLC, GC, NMR, and chiral analysis to confirm identity, purity, and stereochemical integrity. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical specifications. We support compliance with cGMP standards for pharmaceutical ingredient manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) in the original sealed packaging to prevent degradation. For long-term storage, consider storing at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.