Description

5-o-[2-(4-Chlorophenoxy)-2-Methyl-1-Oxopropyl]-2-O,3-O,4-o-Tris(Trimethylsilyl)-D-Glucuronic Acid Methyl Ester is a key protected intermediate in advanced organic synthesis, valued for its role in constructing complex bioactive molecules. Its primary importance lies in enabling precise chemical modifications to the glucuronic acid scaffold, a crucial step in pharmaceutical research and development. This compound is essential for chemists and researchers in the pharmaceutical, agrochemical, and fine chemical industries working on drug discovery, metabolite synthesis, and the development of novel glycosylation methodologies.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel drug candidates, particularly those involving glucuronidation pathways.
• Metabolite Synthesis: Used in the preparation of glucuronide metabolites for pharmacokinetic, pharmacodynamic, and toxicology studies.
• Glycochemistry Research: Serves as a protected glucuronic acid derivative for studying glycosylation reactions and carbohydrate-protein interactions.
• Prodrug Development: Employed in the design and synthesis of prodrugs where glucuronic acid conjugation is used to modify solubility, stability, or bioavailability.
• Agrochemical Synthesis: Potential intermediate in the development of advanced herbicides or plant growth regulators with specific activity profiles.
• Bioconjugation Chemistry: Useful for creating chemically modified biomolecules for diagnostic or therapeutic applications.

Basic Information

Item	Details
Product Name	5-o-[2-(4-Chlorophenoxy)-2-Methyl-1-Oxopropyl]-2-O,3-O,4-o-Tris(Trimethylsilyl)-D-Glucuronic Acid Methyl Ester
CAS No.	55373-82-5
Molecular Formula	C26H43ClO9Si3
Molecular Weight	623.31 g/mol
Synonyms	Methyl 5-O-[2-(4-chlorophenoxy)-2-methylpropanoyl]-2,3,4-tri-O-(trimethylsilyl)-D-glucopyranosiduronate; D-Glucuronic acid, methyl ester, 5-[2-(4-chlorophenoxy)-2-methyl-1-oxopropoxy]-, 2,3,4-tris(trimethylsilyl) ether; Protected D-Glucuronic Acid Methyl Ester Derivative; TMS-Glucuronate Ester Intermediate; CAS 55373-82-5
EINECS	Contact for details

Quality Control

Our production of 5-o-[2-(4-Chlorophenoxy)-2-Methyl-1-Oxopropyl]-2-O,3-O,4-o-Tris(Trimethylsilyl)-D-Glucuronic Acid Methyl Ester adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is analyzed using advanced chromatographic and spectroscopic techniques, including HPLC, NMR, and MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be handled under anhydrous conditions to prevent decomposition. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.