Description

1-(4-Chlorobenzoyl)-5-Methoxy-2-Methyl-1H-Indole-3-Acetic Acid Trimethylsilyl Ester is a key synthetic intermediate, specifically a silyl-protected derivative of a non-steroidal anti-inflammatory drug (NSAID) precursor. Its primary value lies in enabling advanced pharmaceutical synthesis by protecting the carboxylic acid group, which facilitates specific reaction pathways and improves compound stability during manufacturing. This high-purity intermediate is essential for research and development chemists and production facilities engaged in the synthesis of novel therapeutic agents, particularly within the pharmaceutical and fine chemical sectors.

Application

• Pharmaceutical Intermediate: Critical building block in the multi-step synthesis of active pharmaceutical ingredients (APIs), particularly indole-based compounds.
• Research & Development: Used in medicinal chemistry for the discovery and optimization of new drug candidates with anti-inflammatory or analgesic properties.
• Process Chemistry: Employed in scale-up and process development for the commercial manufacturing of target drug molecules.
• Custom Synthesis: Serves as a specialized starting material for contract research organizations (CROs) and CDMOs producing bespoke compounds for clients.
• Reference Standard: Can be utilized as a high-purity analytical standard for quality control and method development in API production.

Basic Information

Product Name	1-(4-Chlorobenzoyl)-5-Methoxy-2-Methyl-1H-Indole-3-Acetic Acid Trimethylsilyl Ester
CAS No.	55334-98-0
Molecular Formula	C22H24ClNO4Si
Molecular Weight	429.97 g/mol
Synonyms	Indomethacin Trimethylsilyl Ester; 1-(p-Chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic Acid Trimethylsilyl Ester; 1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic Acid TMS Ester; TMS-Indomethacin; [1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetic Acid Trimethylsilyl Ester; NSC 339539; Trimethylsilyl 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetate
EINECS	Contact for details

Quality Control

Our production of 1-(4-Chlorobenzoyl)-5-Methoxy-2-Methyl-1H-Indole-3-Acetic Acid Trimethylsilyl Ester adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity suitable for synthetic applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We are committed to meeting the exacting standards required for pharmaceutical intermediates, with quality systems designed to support regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive). Keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation from moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.