Description

1-Trimethylsilyl-3-[2-[(Trimethylsilyl)oxy]ethyl]-1H-indole is a specialized organosilicon derivative of indole, featuring dual trimethylsilyl protecting groups. This compound is highly valued as a key synthetic intermediate and protecting group reagent in advanced organic synthesis, particularly for its role in enhancing reactivity and stability of sensitive molecules. It is primarily utilized by research and development chemists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex heterocyclic frameworks.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the synthesis of novel drug candidates, especially those containing functionalized indole scaffolds.
• Protecting Group Reagent: Used to protect hydroxyl and other sensitive functional groups during multi-step synthetic sequences, facilitating complex molecule assembly.
• Agrochemical Synthesis: Employed in the research and development of advanced pesticides and herbicides that require specific indole-based structures.
• Material Science Research: Acts as a precursor or monomer in the development of novel silicon-containing polymers and advanced organic electronic materials.
• Academic & Industrial R&D: A valuable tool for methodological development in organic chemistry, enabling new routes to complex heterocycles.
• Fine Chemical Production: Used in the custom synthesis of high-value, low-volume specialty chemicals for various technological applications.

Basic Information

Product Name	1-Trimethylsilyl-3-[2-[(Trimethylsilyl)oxy]ethyl]-1H-indole
CAS No.	55334-85-5
Molecular Formula	C₁₈H₃₁NO₂Si₂
Molecular Weight	349.62 g/mol
Synonyms	1H-Indole, 1-(trimethylsilyl)-3-[2-[(trimethylsilyl)oxy]ethyl]-; 3-[2-(Trimethylsilyloxy)ethyl]-1-trimethylsilylindole; 1-TMS-3-(2-(TMS-oxy)ethyl)indole; N,O-Bis(trimethylsilyl) tryptophol derivative; Tryptophol bis(trimethylsilyl) ether; Indole, 1-trimethylsilyl-3-(2-trimethylsilyloxyethyl)-; 55334-85-5; N-TMS-3-(2-O-TMS-ethyl)indole
EINECS	Contact for details

Quality Control

Our 1-Trimethylsilyl-3-[2-[(Trimethylsilyl)oxy]ethyl]-1H-indole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment ensures the material meets the stringent requirements for research and process development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.