Description

2-[(Trimethylsilyl)Oxy]Propenoic Acid [Phosphoric Acid Bis(Trimethylsilyl)]Anhydride is a specialized organosilicon reagent that serves as a powerful silylating agent and reactive intermediate. This compound is valued for its ability to introduce the trimethylsilyl (TMS) protecting group and its role in facilitating specific phosphorylation and esterification reactions under mild conditions. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for synthesizing complex molecules and fine chemicals.

Application

• Pharmaceutical Intermediate Synthesis: Used as a key reagent in the protection of hydroxyl and carboxyl groups during multi-step synthesis of active pharmaceutical ingredients (APIs).
• Agrochemical Production: Employed in the manufacture of advanced pesticides and herbicides where silylation improves reaction selectivity and yield.
• Peptide Chemistry: Facilitates the synthesis and modification of peptides by protecting sensitive functional groups.
• Polymer & Material Science: Acts as a monomer or modifying agent in the production of specialty silicones and functional polymers.
• Analytical Derivatization: Used to prepare volatile derivatives of polar compounds for Gas Chromatography (GC) and Mass Spectrometry (MS) analysis.
• Nucleotide & Carbohydrate Chemistry: Applied in the synthesis of modified nucleosides, nucleotides, and complex sugars.

Basic Information

Item	Details
Product Name	2-[(Trimethylsilyl)Oxy]Propenoic Acid [Phosphoric Acid Bis(Trimethylsilyl)]Anhydride
CAS No.	55334-82-2
Molecular Formula	C9H23O5PSi2
Molecular Weight	298.41 g/mol
Synonyms	Bis(trimethylsilyl) Phosphoro(2-[(trimethylsilyl)oxy]acrylate); Phosphoric Acid Bis(trimethylsilyl) 2-[(Trimethylsilyl)oxy]-2-propenoate; TMS-Pyruvate Phosphoric Anhydride; 2-Propenoic acid, 2-[(trimethylsilyl)oxy]-, (phosphoric acid bis(trimethylsilyl)) anhydride; Silylating Agent 55334-82-2
EINECS	Contact for details

Quality Control

Our production of 2-[(Trimethylsilyl)Oxy]Propenoic Acid [Phosphoric Acid Bis(Trimethylsilyl)]Anhydride adheres to stringent quality management protocols. Each batch is analyzed to ensure high chemical purity and consistency, with specifications tailored to research and industrial application needs. A comprehensive Certificate of Analysis (COA) detailing identity, purity (by NMR, GC, or HPLC), and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC or HPLC)	≥ 95% (Typical: 97-99%)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.