Description

L-Norleucine, n-(Trimethylsilyl)-, Trimethylsilyl Ester is a specialized, high-purity silylated derivative of the non-proteinogenic amino acid L-norleucine. This compound is a critical building block in advanced organic synthesis, particularly for the protection of amino and carboxylic acid functionalities, enabling complex multi-step reactions. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for the synthesis of peptides, peptidomimetics, and other bioactive molecules.

Application

• Pharmaceutical Intermediate: A key protected amino acid derivative for the synthesis of novel peptide-based drugs and active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to introduce the norleucine residue with orthogonal protecting groups.
• Agrochemical Research: Serves as a precursor in the development of new herbicides, fungicides, and plant growth regulators with modified amino acid backbones.
• Proteomics & Biochemistry: Employed as a stable isotope-labeled internal standard (e.g., with 13C, 15N) for mass spectrometry-based quantitative proteomic analysis.
• Material Science: Acts as a monomer or modifying agent in the creation of specialized polymers and bio-conjugates with tailored properties.
• Chemical Biology Tool: Utilized to probe enzyme mechanisms or create synthetic amino acid analogs for structure-activity relationship (SAR) studies.

Basic Information

Item	Details
Product Name	L-Norleucine, n-(Trimethylsilyl)-, Trimethylsilyl Ester
CAS No.	55320-11-1
Molecular Formula	C12H27NO2Si2
Molecular Weight	273.52 g/mol
Synonyms	N-(Trimethylsilyl)-L-norleucine Trimethylsilyl Ester; L-Norleucine, N-(trimethylsilyl)-, trimethylsilyl ester; (S)-2-((Trimethylsilyl)amino)hexanoic acid trimethylsilyl ester; N-TMS-L-norleucine TMS ester; N,O-Bis(trimethylsilyl)-L-norleucine; Protected L-Norleucine; Silylated Norleucine Derivative
EINECS	Contact for details

Quality Control

Our L-Norleucine, n-(Trimethylsilyl)-, Trimethylsilyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for research and process chemistry. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and critical specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (L-Isomer)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.