Description

1-(Trimethylsilyl)-α-[(Trimethylsilyl)Oxy]-1H-Indole-3-Propionic Acid Trimethylsilyl Ester is a highly functionalized, multi-silylated indole derivative that serves as a critical protected intermediate in advanced organic synthesis. Its value lies in providing a stable, reactive platform for constructing complex indole-based molecules, particularly in pharmaceutical research and development. This compound is essential for chemists in the fine chemical, agrochemical, and life science industries who require high-purity building blocks for drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel indole-containing active pharmaceutical ingredients (APIs) and drug candidates.
• Peptidomimetic Research: Used in the development of indole-3-propionic acid derivatives that mimic peptide structures for therapeutic applications.
• Agrochemical Synthesis: Intermediate in the production of advanced crop protection agents and plant growth regulators.
• Material Science Precursor: Serves as a specialized monomer or precursor for functional polymers and advanced organic materials.
• Protecting Group Strategy: The trimethylsilyl (TMS) groups protect reactive carboxylic acid and hydroxyl functionalities during multi-step synthetic sequences.
• Academic & R&D Laboratories: Valuable reagent for methodological development in organic chemistry and exploring new reaction pathways.

Basic Information

Product Name	1-(Trimethylsilyl)-α-[(Trimethylsilyl)Oxy]-1H-Indole-3-Propionic Acid Trimethylsilyl Ester
CAS No.	55319-91-0
Molecular Formula	C20H35NO3Si3
Molecular Weight	441.76 g/mol
Synonyms	1H-Indole-3-propanoic acid, 1-(trimethylsilyl)-α-[(trimethylsilyl)oxy]-, trimethylsilyl ester; 3-(1-Trimethylsilyl-α-trimethylsilyloxyindol-3-yl)propionic Acid Trimethylsilyl Ester; TMS-protected Indole-3-propionic Acid Derivative; Multi-silylated Indole Propionate; 55319-91-0; Tris(trimethylsilyl) Indole-3-propionate Derivative
EINECS	Contact for details

Quality Control

Our production of 1-(Trimethylsilyl)-α-[(Trimethylsilyl)Oxy]-1H-Indole-3-Propionic Acid Trimethylsilyl Ester adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the exacting standards required for synthetic applications. Certificates of Analysis (COA) detailing batch-specific results are provided to guarantee traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0% (Standard Grade)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.