Description

2-[(Trimethylsilyl)Oxy]-3-[1-(Trimethylsilyl)-1H-Indol-3-Yl]Propenoic Acid Trimethylsilyl Ester is a sophisticated, multi-silylated indole derivative that serves as a critical protected intermediate in advanced organic synthesis. Its value lies in enabling complex synthetic routes by providing reactive sites that are shielded from unwanted side reactions, thereby improving yields and selectivity in sensitive transformations. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for the development of novel active ingredients and complex natural product analogs.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of complex indole-based drug candidates, including kinase inhibitors and serotonin receptor modulators.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides that leverage the indole scaffold for biological activity.
• Material Science Research: Serves as a precursor for functionalized organic molecules used in organic light-emitting diodes (OLEDs) and other advanced materials.
• Academic & R&D Laboratories: A valuable reagent for methodological development in organic chemistry, particularly in studies involving silyl protecting groups and cross-coupling reactions.
• Natural Product Synthesis: Employed in the total synthesis of complex indole alkaloids, where its protected functional groups allow for sequential, controlled reactions.

Basic Information

Product Name	2-[(Trimethylsilyl)Oxy]-3-[1-(Trimethylsilyl)-1H-Indol-3-Yl]Propenoic Acid Trimethylsilyl Ester
CAS No.	55319-90-9
Molecular Formula	C22H35NO3Si3
Molecular Weight	449.78 g/mol
Synonyms	3-[1-(Trimethylsilyl)-1H-indol-3-yl]-2-[(trimethylsilyl)oxy]propenoic Acid Trimethylsilyl Ester; (E)-3-[1-(Trimethylsilyl)-1H-indol-3-yl]-2-(trimethylsilyloxy)acrylic Acid Trimethylsilyl Ester; TMS-protected Indole-3-acrylate; Tris(trimethylsilyl) Indoleacrylate; 2-(Trimethylsiloxy)-3-[1-(trimethylsilyl)-1H-indol-3-yl]propenoic Acid Trimethylsilyl Ester
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality protocols to ensure batch-to-batch consistency and high purity, which is critical for sensitive synthetic applications. Each lot is characterized using advanced analytical techniques including NMR, HPLC, and GC-MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.