Description

1,3,5-Trimethyl-5-[3-[(trimethylsilyl)oxy]-1-cyclohexen-1-yl]-2,4,6(1H,3H,5H)-pyrimidinetrione is a specialized organosilicon-protected derivative of a barbituric acid analog, offering a unique combination of a reactive pyrimidinetrione core with a silyl enol ether functional group. This compound is valued for its role as a key synthetic intermediate in advanced organic synthesis, particularly in the construction of complex heterocyclic systems. It is primarily sought by pharmaceutical R&D and fine chemical manufacturers for developing novel active ingredients and high-value specialty chemicals.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel barbiturate analogs and other complex nitrogen-containing heterocycles with potential biological activity.
• Advanced Organic Synthesis: Utilized in multi-step synthetic routes, where the trimethylsilyl (TMS) protecting group allows for selective reactions on other parts of the molecule.
• Medicinal Chemistry Research: Serves as a scaffold for structure-activity relationship (SAR) studies in drug discovery programs targeting the central nervous system (CNS) and other therapeutic areas.
• Fine Chemical Production: Used in the manufacture of high-purity, low-volume specialty chemicals for research and development purposes.
• Academic & Industrial R&D: Employed in methodological development and as a reagent for exploring new synthetic transformations involving silyl enol ethers.

Basic Information

Product Name	1,3,5-Trimethyl-5-[3-[(trimethylsilyl)oxy]-1-cyclohexen-1-yl]-2,4,6(1H,3H,5H)-pyrimidinetrione
CAS No.	55299-22-4
Molecular Formula	C16H26N2O4Si
Molecular Weight	338.48 g/mol
Synonyms	5-[3-[(Trimethylsilyl)oxy]-1-cyclohexen-1-yl]-1,3,5-trimethylpyrimidine-2,4,6(1H,3H,5H)-trione; 1,3,5-Trimethyl-5-(3-trimethylsiloxy-1-cyclohexenyl)barbituric Acid; TMS Enol Ether of 5-(3-Oxo-1-cyclohexenyl)-1,3,5-trimethylbarbituric Acid; Trimethylsilyl 1,3,5-Trimethyl-5-(3-oxo-1-cyclohexen-1-yl)barbiturate Enol Ether; Barbituric Acid, 1,3,5-trimethyl-5-[3-[(trimethylsilyl)oxy]-1-cyclohexen-1-yl]-; CAS 55299-22-4
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management protocols. Each batch is characterized and tested to ensure identity, purity, and consistency, meeting the exacting standards required for pharmaceutical and fine chemical research. A comprehensive Certificate of Analysis (COA) detailing specifications such as assay (HPLC), identity (IR, NMR), and impurity profile is provided with every shipment to guarantee traceability and support your quality assurance processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.