Description

[(Trimethylsilyl)Oxy]Acetaldehyde o-[Bis[(Trimethylsilyl)Oxy]Phosphinyl]Oxime is a specialized organosilicon reagent featuring a unique oxime-phosphinyl protecting group combination. This compound matters as a versatile synthetic intermediate, primarily used for the protection of carbonyl groups and the introduction of phosphinyl functionalities in complex organic synthesis. It is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require high-purity, moisture-sensitive building blocks for developing novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of complex drug candidates, particularly those requiring protected aldehyde or ketone functionalities.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides where its phosphinyl group can be leveraged to create specific bioactive structures.
• Peptide & Carbohydrate Chemistry: Serves as a protecting group reagent for sensitive aldehydes during the multi-step synthesis of peptides, sugars, and nucleosides.
• Material Science Research: Employed in the creation of novel silicon-based polymers and hybrid organic-inorganic materials with tailored properties.
• Cross-Coupling Reactions: Acts as a precursor or modifying agent in metal-catalyzed coupling reactions to construct complex molecular architectures.
• Asymmetric Synthesis: Utilized in chiral synthesis pathways where its specific steric and electronic properties can influence stereoselectivity.

Basic Information

Product Name	[(Trimethylsilyl)Oxy]Acetaldehyde o-[Bis[(Trimethylsilyl)Oxy]Phosphinyl]Oxime
CAS No.	55282-61-6
Molecular Formula	C11H30NO5PSi3
Molecular Weight	383.67 g/mol
Synonyms	Acetaldehyde, [(trimethylsilyl)oxy]-, O-[bis[(trimethylsilyl)oxy]phosphinyl]oxime; O-[Bis(trimethylsiloxy)phosphinyl]hydroxyimino(trimethylsiloxy)ethane; (Trimethylsiloxy)acetaldehyde O-[bis(trimethylsiloxy)phosphinyl]oxime; TMSO-Acetaldehyde O-(TMSO)2P(O)NOH; Silicon-protected acetaldehyde phosphinyl oxime; 55282-61-6; Bis(trimethylsilyl) P-[(E)-(2-trimethylsilyloxyethylidene)amino] phosphate
EINECS	Contact for details

Quality Control

Our [(Trimethylsilyl)Oxy]Acetaldehyde o-[Bis[(Trimethylsilyl)Oxy]Phosphinyl]Oxime is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and scale-up applications. Each lot is analyzed via NMR (¹H, ¹³C, ³¹P), HPLC, and GC to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We adhere to cGMP principles where applicable to support our customers' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) after opening. Store away from incompatible materials such as strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.