Description

(1R)-2β-(5-Methoxy-5-Oxo-2-Pentenyl)-3β,5β-Bis(Trimethylsilyloxy)-1α-Cyclopentanebutanoic Acid Methyl Ester is a high-purity, advanced pharmaceutical intermediate characterized by its complex, functionalized cyclopentane core. This compound is critical for its role in the synthesis of complex bioactive molecules, particularly in prostaglandin and steroid analog research. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical and fine chemical industries for constructing key chiral centers and protecting sensitive hydroxyl groups during multi-step syntheses.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of prostaglandin analogs and other potent bioactive compounds.
• Steroid Chemistry: Used in the research and development of novel steroid derivatives with modified biological activity.
• Asymmetric Synthesis: Serves as a sophisticated substrate for catalytic reactions to introduce specific stereochemistry.
• Process Chemistry: Employed in the scale-up and optimization of synthetic routes for target active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Utilized in lead optimization and structure-activity relationship (SAR) studies for new drug candidates.
• Fine Chemical Production: Acts as a precursor for the manufacture of high-value, specialized chemicals for research and development.

Basic Information

Product Name	(1R)-2β-(5-Methoxy-5-Oxo-2-Pentenyl)-3β,5β-Bis(Trimethylsilyloxy)-1α-Cyclopentanebutanoic Acid Methyl Ester
CAS No.	55282-46-7
Molecular Formula	C24H46O6Si2
Molecular Weight	486.80 g/mol
Synonyms	Methyl (1R,2R,3R,5R)-2-[(5E)-5-Methoxy-5-oxo-2-penten-1-yl]-3,5-bis[(trimethylsilyl)oxy]cyclopentane-1-acetate; (1R,2R,3R,5R)-2-[(5E)-5-Methoxy-5-oxopent-2-en-1-yl]-3,5-bis(trimethylsilyloxy)cyclopentane-1-acetic Acid Methyl Ester; Prostaglandin Intermediate; Corey Lactone Derivative; TMS-protected Prostaglandin Synthon.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is characterized using advanced analytical techniques including NMR, HPLC, and GC-MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profile is provided with every shipment. We support development under cGMP guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere (e.g., nitrogen or argon) when opening the container to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.