Description

N,n-Bis(Trifluoroacetyl)-L-Threonine Butyl Ester is a high-purity, protected amino acid derivative essential for advanced peptide synthesis and pharmaceutical research. This compound serves as a critical chiral building block, enabling the precise construction of complex molecules with defined stereochemistry. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for developing novel therapeutic agents and conducting sophisticated organic synthesis.

Application

• Peptide Synthesis Intermediate: A key protected intermediate in solid-phase and solution-phase peptide synthesis, particularly for incorporating L-threonine residues.
• Pharmaceutical Research & Development: Used as a chiral synthon in the R&D of new active pharmaceutical ingredients (APIs) and prodrugs.
• Proteomics & Biochemical Studies: Employed in the study of protein structure, function, and enzyme-substrate interactions.
• Fine Chemical Manufacturing: Serves as a specialized building block for synthesizing complex organic molecules and custom compounds.
• Reference Standard: Used as a high-purity analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	N,n-Bis(Trifluoroacetyl)-L-Threonine Butyl Ester
CAS No.	55282-41-2
Molecular Formula	C₁₂H₁₅F₆NO₅
Molecular Weight	367.24 g/mol
Synonyms	L-Threonine, N,N-bis(trifluoroacetyl)-, butyl ester; Butyl N,N-bis(trifluoroacetyl)-L-threoninate; N,N-Bis(trifluoroacetyl)threonine butyl ester; (2S,3R)-2-[Bis(trifluoroacetyl)amino]-3-hydroxybutanoic acid butyl ester; BTF-Thr-OBu; N,N-Bis(TFA)-L-Threonine Butyl Ester; TFA-Thr-OtBu (common abbreviation); Protected L-Threonine butyl ester
EINECS	Contact for details

Quality Control

Our N,n-Bis(Trifluoroacetyl)-L-Threonine Butyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation via IR and NMR spectroscopy. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with your research or cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.