Description

1-(Trimethylsilyl)-5-[(Trimethylsilyl)Oxy]-1H-Indole-3-Acetic Acid Trimethylsilyl Ester is a highly functionalized, multi-silylated indole derivative that serves as a critical protected intermediate in advanced organic synthesis. This compound is valued for its role in facilitating complex reactions by masking reactive functional groups, thereby improving solubility and stability during sensitive chemical transformations. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex natural product analogs.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel indole-based drug candidates, including potential anti-inflammatory and neurological agents.
• Agrochemical Research: Used in developing advanced crop protection chemicals and plant growth regulators.
• Complex Natural Product Synthesis: Serves as a protected precursor in the total synthesis of intricate indole alkaloids and other natural products.
• Material Science: Potential monomer or intermediate for creating specialized silicon-containing polymers and advanced materials.
• Chemical Biology Probes: Utilized in the development of labeled compounds and probes for studying biological pathways and enzyme mechanisms.
• Process Chemistry: Employed in route scouting and optimization for scalable manufacturing of fine chemicals.

Basic Information

Product Name	1-(Trimethylsilyl)-5-[(Trimethylsilyl)Oxy]-1H-Indole-3-Acetic Acid Trimethylsilyl Ester
CAS No.	55268-67-2
Molecular Formula	C19H31NO3Si3
Molecular Weight	405.71 g/mol
Synonyms	3-(Trimethylsilyloxy)indole-1-acetic acid trimethylsilyl ester; 5-Hydroxy-1H-indole-3-acetic Acid Tris(trimethylsilyl) Derivative; 1H-Indole-3-acetic acid, 5-hydroxy-, 1-(trimethylsilyl)-, trimethylsilyl ester; TMS-protected 5-Hydroxyindole-3-acetic Acid; Tris(trimethylsilyl) 5-Hydroxyindole-3-acetate
EINECS	Contact for details

Quality Control

Our production of 1-(Trimethylsilyl)-5-[(Trimethylsilyl)Oxy]-1H-Indole-3-Acetic Acid Trimethylsilyl Ester adheres to stringent in-process controls to ensure batch-to-batch consistency and high purity. Each lot is characterized using advanced analytical techniques including NMR, HPLC, and GC-MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.