Description

Trimethylsilyl O,O'-Bis(trimethylsilyl)vanilmandelate is a specialized silyl-protected derivative of vanilmandelic acid, a key intermediate in organic synthesis. This compound is valued for its role in protecting sensitive functional groups, particularly hydroxyl and carboxyl groups, during complex multi-step synthetic sequences. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and fine chemical industries for the synthesis of complex molecules, including active pharmaceutical ingredients (APIs) and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug molecules and active pharmaceutical ingredients (APIs).
• Fine Chemical Synthesis: Used as a versatile protecting group reagent in multi-step organic synthesis for catecholamines and related compounds.
• Research & Development: Essential in laboratory-scale R&D for exploring new synthetic pathways and developing novel chemical entities.
• Process Chemistry: Employed in the scale-up and optimization of manufacturing processes for high-value specialty chemicals.
• Analytical Reference Standard: Serves as a high-purity standard for analytical method development and quality control in pharmaceutical analysis.

Basic Information

Product Name	Trimethylsilyl O,O'-Bis(trimethylsilyl)vanilmandelate
CAS No.	55268-66-1
Molecular Formula	C21H40O5Si3
Molecular Weight	456.78 g/mol
Synonyms	Vanilmandelic Acid Tris(trimethylsilyl) Ester; VMA Tris-TMS; 4-Hydroxy-3-methoxymandelic Acid Tris(trimethylsilyl) Ether; Tris(trimethylsilyl) Vanilmandelate; O,O',O''-Tris(trimethylsilyl)vanilmandelate; 3-Methoxy-4-hydroxymandelic Acid Tris-TMS Derivative; TMS-VMA
EINECS	Contact for details

Quality Control

Our Trimethylsilyl O,O'-Bis(trimethylsilyl)vanilmandelate is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency. Each lot is analyzed using advanced techniques including HPLC, GC, and NMR to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.