Description

n-Trimethylsilyl-L-Aspartic Acid Bis(Trimethylsilyl) Ester is a high-purity, protected derivative of the amino acid L-aspartic acid, extensively utilized as a key synthetic intermediate in advanced organic and peptide chemistry. Its primary value lies in its role as a versatile building block for the synthesis of complex peptides, modified amino acids, and other bioactive molecules, offering enhanced solubility and protection of reactive functional groups during multi-step reactions. This compound is essential for research and development laboratories, pharmaceutical manufacturers, and fine chemical producers focused on peptide-based drug discovery, proteomics research, and the development of novel therapeutic agents.

Application

• Peptide Synthesis: A crucial protected intermediate for the solid-phase and solution-phase synthesis of peptides containing aspartic acid, preventing unwanted side reactions.
• Pharmaceutical Intermediates: Serves as a key building block in the production of active pharmaceutical ingredients (APIs) and drug candidates, particularly in oncology and neurology research.
• Proteomics & Biochemical Research: Used in the study of protein structure and function, and in the preparation of isotopically labeled amino acids for mass spectrometry.
• Fine Chemical Manufacturing: Employed in the synthesis of specialized amino acid derivatives, chiral auxiliaries, and other high-value organic compounds.
• Agrochemical Development: Acts as an intermediate in the research and synthesis of novel peptide-based pesticides and herbicides.
• Material Science: Potential use in the development of specialized polymers and biomaterials that incorporate amino acid motifs.

Basic Information

Product Name	n-Trimethylsilyl-L-Aspartic Acid Bis(Trimethylsilyl) Ester
CAS No.	55268-53-6
Molecular Formula	C13H31NO4Si3
Molecular Weight	349.65 g/mol
Synonyms	L-Aspartic Acid, N-(trimethylsilyl)-, bis(trimethylsilyl) ester; N-Trimethylsilyl-L-aspartic Acid Bis(trimethylsilyl) Ester; N-TMS-L-Aspartic Acid Bis(TMS) Ester; (2S)-2-[(Trimethylsilyl)amino]butanedioic Acid Bis(trimethylsilyl) Ester; N,O,O-Tris(trimethylsilyl)-L-aspartate; Protected L-Aspartic Acid TMS Ester; Aspartic Acid TMS Derivative
EINECS	Contact for details

Quality Control

Our n-Trimethylsilyl-L-Aspartic Acid Bis(Trimethylsilyl) Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity suitable for sensitive synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as assay, enantiomeric purity, and impurity profiles. We adhere to cGMP guidelines where applicable, and our quality management system is designed to meet the stringent requirements of the pharmaceutical and biotechnology industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its highly volatile and hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation and moisture absorption. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.