Description

1-(Trimethylsilyl)-1H-Indole-5-Carboxylic Acid Trimethylsilyl Ester is a high-value, dual-protected indole derivative, serving as a critical synthetic intermediate in advanced organic chemistry. Its core value lies in providing a stable, reactive platform for constructing complex heterocyclic systems, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries who require reliable, high-purity building blocks for API synthesis and novel compound libraries.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel indole-based active pharmaceutical ingredients (APIs) and drug candidates, particularly for central nervous system (CNS) and anti-inflammatory targets.
• Agrochemical Synthesis: Used in the research and development of new generation herbicides, fungicides, and plant growth regulators that utilize functionalized indole scaffolds.
• Material Science Precursor: Serves as a monomer or functionalizing agent in the development of specialty polymers, organic semiconductors, and advanced organic electronic materials.
• Organic Synthesis Reagent: Employed in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) and other metal-mediated transformations to introduce the indole-5-carboxylate moiety into complex molecules.
• Chemical Research & Development: A versatile starting material in academic and industrial R&D for exploring new heterocyclic chemistry and developing novel synthetic methodologies.
• Ligand Synthesis: Used to prepare sophisticated nitrogen-containing ligands for catalysis and coordination chemistry.

Basic Information

Item	Details
Product Name	1-(Trimethylsilyl)-1H-Indole-5-Carboxylic Acid Trimethylsilyl Ester
CAS No.	55255-79-3
Molecular Formula	C16H25NO2Si2
Molecular Weight	319.55 g/mol
Synonyms	5-Carboxy-1-(trimethylsilyl)indole trimethylsilyl ester; 1H-Indole-5-carboxylic acid, 1-(trimethylsilyl)-, trimethylsilyl ester; 1-TMS-indole-5-carboxylic acid TMS ester; 1-Trimethylsilyl-1H-indole-5-carboxylic acid trimethylsilyl ester; N-TMS-5-TMS-oxycarbonylindole; 5-(Trimethylsiloxycarbonyl)-1-(trimethylsilyl)indole; Bis(trimethylsilyl) indole-5-carboxylate; N,O-Bis(trimethylsilyl) indole-5-carboxylate
EINECS	Contact for details

Quality Control

Our 1-(Trimethylsilyl)-1H-Indole-5-Carboxylic Acid Trimethylsilyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP, ICH Q7, and other relevant pharmaceutical and chemical industry standards for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.