Description

4-Phenyl-1-(Trimethylsilyl)-4-Piperidinecarboxylic Acid Ethyl Ester is a high-value, organosilicon-protected piperidine derivative that serves as a critical synthetic intermediate. Its core value lies in providing a sterically hindered, protected amine functionality essential for constructing complex pharmacologically active molecules. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of new chemical entities, particularly within medicinal chemistry and process research.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates targeting the central nervous system (CNS) and other therapeutic areas.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its versatile piperidine scaffold.
• Process Chemistry Development: Serves as a protected intermediate in the scale-up and optimization of synthetic routes for active pharmaceutical ingredients (APIs).
• Organosilicon Chemistry: Valuable substrate for studying silyl group transfer reactions and the stability of silyl-protected amines under various conditions.
• Custom Synthesis: Starting material for the preparation of more complex, tailored molecules for specialized research and development projects.

Basic Information

Product Name	4-Phenyl-1-(Trimethylsilyl)-4-Piperidinecarboxylic Acid Ethyl Ester
CAS No.	55255-40-8
Molecular Formula	C17H27NO2Si
Molecular Weight	305.49 g/mol
Synonyms	Ethyl 4-Phenyl-1-(trimethylsilyl)-4-piperidinecarboxylate; 1-(Trimethylsilyl)-4-phenyl-4-piperidinecarboxylic Acid Ethyl Ester; 4-Phenyl-1-(trimethylsilyl)isonipecotic Acid Ethyl Ester; 4-Phenyl-1-(trimethylsilyl)piperidine-4-carboxylic Acid Ethyl Ester; 55255-40-8; Ethyl 1-(Trimethylsilyl)-4-phenylpiperidine-4-carboxylate
EINECS	Contact for details

Quality Control

Our 4-Phenyl-1-(Trimethylsilyl)-4-Piperidinecarboxylic Acid Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all relevant specifications. Our commitment to quality supports compliance with cGMP standards for pharmaceutical research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which may affect product stability and performance.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.