Description

4-(Trimethylsiloxy)Butanoic Acid Trimethylsilyl Ester is a versatile organosilicon compound, primarily valued as a key protected intermediate in organic synthesis. Its dual silyl protection makes it an essential reagent for the controlled introduction of the 4-butanoic acid moiety under non-aqueous conditions. This compound is particularly critical for researchers and manufacturers in the pharmaceutical and fine chemical sectors who require high-purity, moisture-sensitive building blocks for complex molecule assembly.

Application

• Pharmaceutical Intermediate: A key protected synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly those containing carboxylic acid or γ-hydroxybutyric acid (GHB) related structures.
• Peptide & Nucleotide Synthesis: Used in the preparation of protected amino acid derivatives and nucleoside analogs where temporary silyl protection of carboxylic acid groups is required.
• Fine Chemical Synthesis: Serves as a crucial building block in the multi-step synthesis of complex organic molecules, agrochemicals, and specialty materials.
• Silicon Chemistry Research: Employed in the study of silyl ester chemistry, including trans-silylation reactions and the development of new silylating agents.
• Polymer Modification: Can be used to introduce functional siloxane groups into polymer backbones or as a monomer for specialty silicone-containing polymers.

Basic Information

Product Name	4-(Trimethylsiloxy)Butanoic Acid Trimethylsilyl Ester
CAS No.	55133-95-4
Molecular Formula	C10H24O3Si2
Molecular Weight	248.47 g/mol
Synonyms	Butanoic acid, 4-(trimethylsiloxy)-, trimethylsilyl ester; 4-(Trimethylsilyloxy)butanoic Acid Trimethylsilyl Ester; 4-[(Trimethylsilyl)oxy]butanoic Acid Trimethylsilyl Ester; 4-TMS-O-Butyric Acid TMS Ester; γ-(Trimethylsiloxy)butyric Acid Trimethylsilyl Ester; GHB Bis(trimethylsilyl) Ether; 4-Hydroxybutyric Acid Bis(trimethylsilyl) Ether; 4-(TMS-oxy)butyric Acid TMS Ester
EINECS	Contact for details

Quality Control

Our production of 4-(Trimethylsiloxy)Butanoic Acid Trimethylsilyl Ester adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. All material is characterized by GC, NMR, and IR spectroscopy to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing assay, impurity profile, and physical properties is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon or nitrogen) to prevent hydrolysis. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.