Description

2-Methyl-2-[(Trimethylsilyl)Oxy]Propionic Acid Trimethylsilyl Ester is a versatile organosilicon reagent featuring a fully silylated α-hydroxy acid structure. This compound is valued for its role as a highly effective protecting group and as a key synthetic intermediate in complex organic transformations. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for the synthesis of active pharmaceutical ingredients (APIs) and specialty chemicals.

Application

• Pharmaceutical Synthesis: As a crucial protecting group for carboxylic acids and α-hydroxy acids during multi-step synthesis of complex drug molecules and APIs.
• Peptide Chemistry: Used to protect sensitive amino acid side chains, preventing unwanted side reactions during solid-phase and solution-phase peptide synthesis.
• Agrochemical Intermediate: Serves as a building block in the production of advanced herbicides, fungicides, and plant growth regulators.
• Polymer Modification: Employed to introduce silyl ether functionalities into polymer backbones, altering solubility and thermal properties for specialty materials.
• Chemical Derivatization: Utilized in analytical chemistry for the derivatization of polar compounds (e.g., acids, alcohols) to improve their volatility for Gas Chromatography (GC) analysis.
• Cross-Coupling Reactions: Acts as a reagent in palladium-catalyzed cross-coupling reactions to construct complex carbon-carbon bonds.

Basic Information

Product Name	2-Methyl-2-[(Trimethylsilyl)Oxy]Propionic Acid Trimethylsilyl Ester
CAS No.	55133-92-1
Molecular Formula	C10H24O3Si2
Molecular Weight	248.47 g/mol
Synonyms	2-(Trimethylsiloxy)-2-methylpropanoic Acid Trimethylsilyl Ester; α-Hydroxyisobutyric Acid Bis(trimethylsilyl) Ester; Bis(trimethylsilyl) 2-Hydroxy-2-methylpropionate; 2-Hydroxy-2-methylpropionic Acid Bis(trimethylsilyl) Ester; Bis-TMS Ester of 2-Hydroxyisobutyric Acid; TMS Ester of 2-(Trimethylsiloxy)-2-methylpropanoic Acid; 2-Methyl-2-(trimethylsiloxy)propionic Acid TMS Ester
EINECS	Contact for details

Quality Control

Our production of 2-Methyl-2-[(Trimethylsilyl)Oxy]Propionic Acid Trimethylsilyl Ester adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. All materials are characterized by GC, NMR, and IR spectroscopy. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and highly volatile; containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation and moisture uptake.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.