Description

2-[(Trimethylsilyl)Oxy]Isovaleric Acid Trimethylsilyl Ester is a versatile organosilicon reagent featuring a fully protected carboxylic acid group. This compound is crucial for synthetic organic chemistry, particularly in multi-step synthesis where temporary protection of sensitive functional groups is required. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for the controlled introduction of isovaleric acid derivatives.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of active pharmaceutical ingredients (APIs), especially for compounds requiring the isovalerate moiety under anhydrous conditions.
• Peptide Synthesis: Used as a protected carboxylic acid derivative in solid-phase and solution-phase peptide coupling reactions to prevent side reactions.
• Agrochemical Synthesis: Employed in the production of advanced herbicides and fungicides where the silyl ester group offers superior reactivity and selectivity.
• Polymer Modification: Acts as a functional monomer or cross-linking agent in the synthesis of specialty silicones and silicon-containing polymers.
• Derivatization Agent: Utilized in analytical chemistry for the silylation of compounds for Gas Chromatography (GC) or Mass Spectrometry (MS) analysis to improve volatility and detection.
• Fragrance and Flavor Synthesis: Provides a protected form of isovaleric acid for the controlled synthesis of esters used in complex fragrance compositions.

Basic Information

Product Name	2-[(Trimethylsilyl)Oxy]Isovaleric Acid Trimethylsilyl Ester
CAS No.	55124-92-0
Molecular Formula	C11H26O3Si2
Molecular Weight	262.50 g/mol
Synonyms	3-Methylbutanoic Acid, 2-(Trimethylsiloxy)-, Trimethylsilyl Ester; 2-(Trimethylsiloxy)-3-methylbutyric Acid Trimethylsilyl Ester; Isovaleric Acid, 2-(Trimethylsiloxy)-, Trimethylsilyl Ester; Bis(trimethylsilyl) 2-Hydroxyisovalerate; TMS-Protected 2-Hydroxyisovaleric Acid
EINECS	Contact for details

Quality Control

Our 2-[(Trimethylsilyl)Oxy]Isovaleric Acid Trimethylsilyl Ester is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for research and industrial synthesis. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards and can provide material tailored to specific project requirements, including cGMP-grade where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at temperatures between 2°C and 8°C (refrigerated) to minimize volatility and degradation. Due to its hygroscopic and highly volatile nature, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening and allowed to equilibrate to room temperature before use to prevent moisture ingress.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.