Description

[1-(Isopropylideneamino)-2-Phenylethyl]Phosphonic Acid Bis(Trimethylsilyl) Ester is a specialized organophosphorus compound featuring both phosphonate and silyl ether protecting groups. This compound is a critical synthetic intermediate, valued for its role in facilitating complex organic transformations, particularly in the construction of phosphorus-containing molecules. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel drug candidates, particularly those targeting bone diseases or requiring phosphonate bioisosteres.
• Agrochemical Research: Used in the development of new herbicides, insecticides, and plant growth regulators that incorporate phosphonic acid derivatives.
• Ligand Synthesis: Acts as a precursor for the creation of sophisticated phosphonate-based ligands used in catalysis and metal coordination chemistry.
• Material Science: Employed in the research and development of flame retardants, surface modifiers, and specialty polymers.
• Process Chemistry: Utilized in scalable routes for the protected synthesis of phosphonic acids, where the trimethylsilyl groups offer advantageous solubility and handling properties.
• Academic & R&D: A valuable reagent for methodological development in organic synthesis, enabling new pathways to complex organophosphorus compounds.

Basic Information

Product Name	[1-(Isopropylideneamino)-2-Phenylethyl]Phosphonic Acid Bis(Trimethylsilyl) Ester
CAS No.	55108-69-5
Molecular Formula	C17H32NO3PSi2
Molecular Weight	385.59 g/mol
Synonyms	Bis(trimethylsilyl) [1-(isopropylideneamino)-2-phenylethyl]phosphonate; Phosphonic acid, [1-(isopropylideneamino)-2-phenylethyl]-, bis(trimethylsilyl) ester; (Isopropylideneamino)(2-phenylethyl)phosphonic Acid Bis(trimethylsilyl) Ester; TMS-Protected Phosphonate Ester; α-Aminophosphonate TMS Ester; N-(1-Diethoxyphosphoryl-2-phenylethylidene)propan-2-amine Bis(trimethylsilyl) Ester (related); Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our [1-(Isopropylideneamino)-2-Phenylethyl]Phosphonic Acid Bis(Trimethylsilyl) Ester is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including NMR, HPLC, and GC, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing batch-specific results are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.