Description

[1-(Isopropylideneamino)Ethyl]Phosphonic Acid Bis(Trimethylsilyl) Ester is a specialized organophosphorus compound featuring a protected phosphonic acid group, making it a valuable reagent in advanced synthetic chemistry. This compound matters for its role as a key synthetic intermediate and protecting group strategy, enabling precise molecular construction in sensitive applications. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for the synthesis of complex molecules, including active pharmaceutical ingredients (APIs) and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a protected phosphonate building block in the multi-step synthesis of novel drug candidates, particularly those targeting bone diseases or requiring phosphate bioisosteres.
• Agrochemical Synthesis: Used in the research and development of new herbicides, plant growth regulators, and other crop protection agents where phosphonate chemistry is required.
• Ligand and Catalyst Preparation: Acts as a precursor for the synthesis of specialized phosphonate-based ligands used in coordination chemistry and homogeneous catalysis.
• Materials Science Research: Employed in the development of surface-modifying agents, metal-organic frameworks (MOFs), and other functional materials where a silyl-protected phosphonic acid group is advantageous.
• Process Chemistry Development: Utilized in route scouting and optimization for the scalable production of complex organic molecules, offering a stable, handleable form of a reactive phosphonate anion equivalent.

Basic Information

Product Name	[1-(Isopropylideneamino)Ethyl]Phosphonic Acid Bis(Trimethylsilyl) Ester
CAS No.	55108-64-0
Molecular Formula	C11H28NO3PSi2
Molecular Weight	309.50 g/mol
Synonyms	Phosphonic acid, P-[1-[(1-methylethylidene)amino]ethyl]-, bis(trimethylsilyl) ester; Bis(trimethylsilyl) [1-(isopropylideneamino)ethyl]phosphonate; [1-(Isopropylideneamino)ethyl]phosphonic Acid Bis(trimethylsilyl) Ester; (1-Isopropylideneaminoethyl)phosphonic Acid Bis(trimethylsilyl) Ester; Trimethylsilyl [1-(isopropylideneamino)ethyl]phosphonate; N-(1-Phosphonatoethyl)acetimidic Acid Bis(trimethylsilyl) Ester
EINECS	Contact for details

Quality Control

Every batch of [1-(Isopropylideneamino)Ethyl]Phosphonic Acid Bis(Trimethylsilyl) Ester undergoes rigorous analytical testing to ensure identity, purity, and consistency suitable for research and development applications. Our quality commitment includes adherence to in-house specifications developed for high-purity synthetic intermediates. Certificates of Analysis (COA) detailing purity by NMR and/or HPLC are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Purity (NMR)	≥ 95.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.