Description

5-Isocyanato-2-(4-Thiazolyl)-1H-Benzimidazole is a specialized heterocyclic building block that combines benzimidazole and thiazole pharmacophores with a reactive isocyanate group. This unique structure makes it a critical intermediate for the synthesis of novel compounds with potential biological activity. It is primarily sought after by pharmaceutical research and agrochemical development teams for creating targeted small molecule libraries and advanced active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates targeting various enzymes and receptors.
• Agrochemical Research: Used in developing new generation pesticides and herbicides with specific modes of action.
• Chemical Biology Probe Development: Serves as a precursor for creating activity-based probes to study biological processes.
• Material Science: Potential monomer for synthesizing specialty polymers with unique thermal or optical properties.
• Organic Synthesis: Versatile reagent for constructing complex heterocyclic frameworks via urea/thiourea linkages.

Basic Information

Product Name	5-Isocyanato-2-(4-Thiazolyl)-1H-Benzimidazole
CAS No.	55044-84-3
Molecular Formula	C11H6N4OS
Molecular Weight	242.26 g/mol
Synonyms	2-(1,3-Thiazol-4-yl)-1H-benzimidazol-5-yl isocyanate; 5-Isocyanato-2-(1,3-thiazol-4-yl)-1H-benzimidazole; 2-(Thiazol-4-yl)-1H-benzimidazole-5-isocyanate; 4-(5-Isocyanato-1H-benzimidazol-2-yl)thiazole; 55044-84-3; 5-Isocyanato-2-(4-thiazolyl)benzimidazole
EINECS	Contact for details

Quality Control

Our 5-Isocyanato-2-(4-Thiazolyl)-1H-Benzimidazole is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the exacting standards required for research and development. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its moisture-sensitive and light-sensitive nature. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Solubility	Soluble in DMF, DMSO; sparingly soluble in common organic solvents

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.