Description

1-(Trifluoroacetyl)-4-Piperidinecarboxylic Acid (S)-1-Methylpropyl Ester is a high-purity, advanced pharmaceutical intermediate characterized by its chiral center and trifluoroacetyl protecting group. This compound matters as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting the central nervous system. Pharmaceutical R&D and manufacturing organizations need it for developing and scaling up production of novel therapeutic agents, where its specific stereochemistry and functional groups are essential for achieving desired biological activity and pharmacokinetic profiles.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of potent drug candidates, especially in neurology and psychiatry.
• API Development: Used in research and process chemistry for constructing the core piperidine scaffold of target molecules.
• Medicinal Chemistry: Serves as a versatile precursor for structure-activity relationship (SAR) studies and lead optimization.
• Process Scale-up: Employed in pilot plant and commercial manufacturing under current Good Manufacturing Practice (cGMP) conditions.
• Asymmetric Synthesis: Utilized in reactions requiring high enantiomeric purity due to its defined (S)-configuration.
• Chemical Reference Standard: Acts as a high-purity standard for analytical method development and quality control in API production.

Basic Information

Product Name	1-(Trifluoroacetyl)-4-Piperidinecarboxylic Acid (S)-1-Methylpropyl Ester
CAS No.	55044-14-9
Molecular Formula	C12H18F3NO3
Molecular Weight	281.27 g/mol
Synonyms	(S)-1-Methylpropyl 1-(Trifluoroacetyl)piperidine-4-carboxylate; (S)-sec-Butyl 1-(Trifluoroacetyl)piperidine-4-carboxylate; 4-Piperidinecarboxylic acid, 1-(trifluoroacetyl)-, (1S)-1-methylpropyl ester; 1-(Trifluoroacetyl)-4-piperidinecarboxylic acid (S)-sec-butyl ester; (S)-1-Methylpropyl 4-(trifluoroacetyl)piperidine-1-carboxylate; (S)-sec-Butyl 4-(trifluoroacetyl)piperidine-1-carboxylate; 55044-14-9; (S)-1-Methylpropyl 1-(2,2,2-trifluoroacetyl)piperidine-4-carboxylate
EINECS	Contact for details

Quality Control

Our 1-(Trifluoroacetyl)-4-Piperidinecarboxylic Acid (S)-1-Methylpropyl Ester is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for demanding pharmaceutical applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, chiral purity, and impurity profiles. Our quality commitment aligns with ICH guidelines, and material can be supplied under cGMP standards for advanced clinical and commercial API manufacturing upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.