Description

Acetic Acid, Iodo-, Trimethylsilyl Ester is a specialized organosilicon reagent featuring a silyl-protected iodoacetate group. This compound is a valuable synthetic intermediate, prized for its ability to introduce the iodoacetyl moiety under mild conditions while offering enhanced stability and solubility in organic media compared to iodoacetic acid. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for the synthesis of complex molecules, including active pharmaceutical ingredients (APIs) and functional polymers.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in creating alkylating agents or conjugating pharmacophores.
• Bioconjugation Reagent: Used for labeling peptides, proteins, and antibodies via reaction with thiol or amine groups, useful in probe and ADC (Antibody-Drug Conjugate) development.
• Polymer Modification: Serves as a functional monomer or cross-linking agent to introduce iodine-containing groups into polymers for specialty materials.
• Organic Synthesis: Employed in palladium-catalyzed cross-coupling reactions (e.g., Sonogashira, Heck) and as a source of the iodoacetate anion equivalent.
• Agrochemical Research: Intermediate in the preparation of herbicidal or fungicidal compounds requiring halogenated acetate structures.
• Material Science: Precursor for surface functionalization of silicon-based materials and nanoparticles.

Basic Information

Product Name	Acetic Acid, Iodo-, Trimethylsilyl Ester
CAS No.	55030-41-6
Molecular Formula	C5H11IO2Si
Molecular Weight	258.13 g/mol
Synonyms	Trimethylsilyl iodoacetate; Iodoacetic Acid Trimethylsilyl Ester; (Iodoacetoxy)trimethylsilane; TMS-Iodoacetate; Silane, (iodoacetoxy)trimethyl-; Acetic acid, iodo-, 1-(trimethylsilyl) ester; Iodoacetic acid TMS ester
EINECS	Contact for details

Quality Control

Every batch of Acetic Acid, Iodo-, Trimethylsilyl Ester is produced and analyzed under strict quality management protocols. We ensure high purity and batch-to-batch consistency through comprehensive analytical testing, including GC, HPLC, and NMR. A detailed Certificate of Analysis (COA) documenting identity, purity, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when prolonged exposure is anticipated to maintain purity and reactivity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.