Description

(S)-2-[Methyl(Trifluoroacetyl)Amino]Propionic Acid (S)-1-Methylpropyl Ester is a chiral, non-racemic building block of significant importance in advanced organic synthesis. Its core value lies in providing a protected amino acid derivative with a stereodefined center, enabling the controlled construction of complex molecules. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing active pharmaceutical ingredients (APIs) and chiral ligands.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of enantiomerically pure drugs, especially peptidomimetics and protease inhibitors.
• Agrochemical Synthesis: Used in the research and production of chiral pesticides and herbicides where specific stereochemistry is required for biological activity.
• Asymmetric Catalysis: Serves as a precursor for chiral auxiliaries, ligands, or catalysts used in stereoselective transformations.
• Peptide Chemistry: Employed in the preparation of modified amino acids and small peptides with tailored properties for biochemical research.
• Chemical Research & Development: A valuable tool for medicinal chemists and process chemists exploring new synthetic routes and novel molecular entities.
• Reference Standard: Used as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	(S)-2-[Methyl(Trifluoroacetyl)Amino]Propionic Acid (S)-1-Methylpropyl Ester
CAS No.	54986-65-1
Molecular Formula	C9H14F3NO3
Molecular Weight	241.21 g/mol
Synonyms	(S)-1-Methylpropyl (S)-2-[methyl(trifluoroacetyl)amino]propanoate; L-Alanine, N-methyl-N-(trifluoroacetyl)-, (S)-1-methylpropyl ester; (S)-2-(Methyl(trifluoroacetamido))propionic acid (S)-sec-butyl ester; (S)-sec-Butyl (S)-2-[methyl(trifluoroacetyl)amino]propionate; N-Methyl-N-trifluoroacetyl-L-alanine (S)-sec-butyl ester; Chiral Alanine Derivative Ester; Trifluoroacetyl-Methyl-Alanine sec-Butyl Ester
EINECS	Contact for details

Quality Control

Our production of (S)-2-[Methyl(Trifluoroacetyl)Amino]Propionic Acid (S)-1-Methylpropyl Ester adheres to stringent quality protocols to ensure batch-to-batch consistency and high enantiomeric purity, critical for sensitive synthetic applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity (by HPLC), chiral purity, and impurity profiles. We operate under a cGMP-compliant quality management system, and specifications can be tailored to meet the rigorous demands of pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.