Description

3-Methyl-n-(Trimethylsilyl)-3H-Purin-6-Amine is a specialized organosilicon-modified purine derivative, serving as a key synthetic intermediate in advanced organic chemistry. Its value lies in the trimethylsilyl (TMS) protecting group, which enhances solubility and stability during complex reaction sequences, particularly in nucleoside and nucleotide chemistry. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients, as well as in academic settings for probing biochemical pathways.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of modified nucleosides, nucleotides, and related analogs with potential antiviral or anticancer activity.
• Agrochemical Research: Used in the development of novel plant growth regulators or pesticides that target specific biochemical pathways in pests or weeds.
• Biochemical Probe Synthesis: Facilitates the creation of labeled or modified purine derivatives for studying enzyme mechanisms, receptor binding, and metabolic processes.
• Organic Synthesis Reagent: Acts as a protected amine donor or a silylated reactant in multi-step synthetic routes requiring selective functional group manipulation.
• Material Science Precursor: Potential use in the synthesis of organic semiconductors or conductive polymers where modified purine cores are required.

Basic Information

Product Name	3-Methyl-n-(Trimethylsilyl)-3H-Purin-6-Amine
CAS No.	54965-56-9
Molecular Formula	C9H15N5Si
Molecular Weight	221.34 g/mol
Synonyms	6-Amino-3-methyl-1-(trimethylsilyl)purine; 3-Methyl-6-(trimethylsilylamino)purine; N-(Trimethylsilyl)-3-methyl-3H-purin-6-amine; 3-Methyl-1-(trimethylsilyl)-1H-purin-6-amine; 6-Amino-3-methyl-1-(trimethylsilyl)-1H-purine; 3-Methyl-6-(trimethylsilylamino)-1H-purine; TMS-protected 3-methyladenine derivative
EINECS	Contact for details

Quality Control

Our production of 3-Methyl-n-(Trimethylsilyl)-3H-Purin-6-Amine adheres to stringent internal quality standards to ensure batch-to-batch consistency and high purity for research and development applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity assessment and NMR for structural confirmation. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere (e.g., nitrogen or argon) when opening the primary container to prevent degradation. For long-term storage, consider desiccants.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.