Description

4-Methyl-2-[(Trimethylsilyl)Oxy]Pentanoic Acid Trimethylsilyl Ester is a specialized organosilicon compound, specifically a fully silylated derivative of a branched-chain carboxylic acid. This chemical is valued for its role as a key synthetic intermediate and protecting group reagent in advanced organic synthesis, particularly for sensitive or complex molecules. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing and modifying molecular architectures under mild conditions.

Application

• Pharmaceutical Intermediate: Used in the synthesis of active pharmaceutical ingredients (APIs), particularly where protection of carboxylic acid or hydroxyl groups is required.
• Agrochemical Synthesis: Serves as a building block for creating novel pesticides, herbicides, and plant growth regulators.
• Peptide Chemistry: Employed as a protecting group reagent for amino acids during solid-phase or solution-phase peptide synthesis.
• Advanced Material Precursor: Acts as a monomer or modifying agent in the production of specialty silicones and silicon-containing polymers.
• Organic Synthesis Reagent: Facilitates various reactions, including esterifications and condensations, by providing a temporary trimethylsilyl (TMS) protecting group.
• Analytical Chemistry: Used to derivative compounds for Gas Chromatography-Mass Spectrometry (GC-MS) analysis to improve volatility and detection.

Basic Information

Product Name	4-Methyl-2-[(Trimethylsilyl)Oxy]Pentanoic Acid Trimethylsilyl Ester
CAS No.	54890-08-3
Molecular Formula	C12H28O3Si2
Molecular Weight	276.52 g/mol
Synonyms	2-(Trimethylsiloxy)-4-methylpentanoic acid trimethylsilyl ester; 4-Methyl-2-(trimethylsiloxy)pentanoic acid TMS ester; Bis(trimethylsilyl) 4-methyl-2-(trimethylsiloxy)pentanoate; Leucine derivative TMS ester; TMS-Leucine TMS ester; (Trimethylsilyl) 4-methyl-2-[(trimethylsilyl)oxy]pentanoate; 2-Hydroxy-4-methylpentanoic acid bis(trimethylsilyl) ether
EINECS	Contact for details

Quality Control

Our production of 4-Methyl-2-[(Trimethylsilyl)Oxy]Pentanoic Acid Trimethylsilyl Ester adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for research and process-scale applications. Each lot is analyzed using advanced chromatographic and spectroscopic techniques. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.