Description

n-(Trifluoroacetyl)-D-Isovaline 1-Methylpropyl Ester is a high-purity, non-natural amino acid derivative characterized by its trifluoroacetyl protecting group and chiral D-isovaline backbone. This compound is a critical chiral building block and intermediate in advanced organic synthesis, particularly valued for its role in introducing sterically hindered, non-proteinogenic amino acid motifs. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel peptides, peptidomimetics, and active pharmaceutical ingredients (APIs) where structural complexity and chiral purity are paramount.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of new therapeutic agents, including protease inhibitors and receptor antagonists.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis to incorporate the unique, sterically constrained D-isovaline residue into peptide sequences.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to explore the impact of non-standard amino acids on drug potency, selectivity, and metabolic stability.
• Asymmetric Synthesis: Acts as a chiral auxiliary or starting material in the synthesis of complex, enantiomerically pure molecules for agrochemical and fine chemical applications.
• Biochemical Tool Development: Utilized in the design and synthesis of enzyme substrates, inhibitors, and probes for biochemical and biophysical studies.

Basic Information

Item	Details
Product Name	n-(Trifluoroacetyl)-D-Isovaline 1-Methylpropyl Ester
CAS No.	54889-84-8
Molecular Formula	C11H18F3NO3
Molecular Weight	269.26 g/mol
Synonyms	D-Isovaline, N-trifluoroacetyl-, 1-methylpropyl ester; (R)-2-Amino-2-methylbutanoic Acid N-Trifluoroacetyl 1-Methylpropyl Ester; N-(Trifluoroacetyl)-D-isovaline isobutyl ester; 1-Methylpropyl (2R)-2-[(2,2,2-trifluoroacetyl)amino]-2-methylbutanoate; TFA-D-Iva-OiBu; Trifluoroacetyl-D-isovaline isobutyl ester
EINECS	Contact for details

Quality Control

Our n-(Trifluoroacetyl)-D-Isovaline 1-Methylpropyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for pharmaceutical research and development. A detailed Certificate of Analysis (COA) documenting identity, purity, and chiral excess is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This material is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if necessary.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.