Description

4,5-Dihydro-4-Methylenespiro[Furan-2(3H),3'-[2]Oxabicyclo[2.2.2]Oct[5]Ene]-6'-Carbonitrile is a specialized, high-value spirocyclic organic compound featuring a unique fused ring system. This complex molecular architecture makes it a critical advanced intermediate for synthesizing novel chemical entities, particularly in the development of active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily sought after by research institutions and industrial R&D departments focused on medicinal chemistry and fine chemical synthesis.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of complex drug candidates, especially those targeting neurological or inflammatory pathways.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, or insecticides with new modes of action.
• Material Science: Potential precursor for creating specialty polymers or liquid crystals with unique optical or electronic properties.
• Academic & Contract Research: Employed in methodological studies and the discovery of new chemical reactions (e.g., cycloadditions) due to its strained, multifunctional structure.
• Fine Chemical Synthesis: Acts as a versatile intermediate for producing other spirocyclic or bridged compounds used in fragrances, dyes, or catalysts.

Basic Information

Product Name	4,5-Dihydro-4-Methylenespiro[Furan-2(3H),3'-[2]Oxabicyclo[2.2.2]Oct[5]Ene]-6'-Carbonitrile
CAS No.	54852-61-8
Molecular Formula	C12H11NO2
Molecular Weight	201.22 g/mol
Synonyms	6'-Cyano-4-methylenespiro[2-oxabicyclo[2.2.2]oct-5-ene-3,2'-(4,5-dihydrofuran)]; 4-Methylenespiro[furan-2(3H),3'-[2]oxabicyclo[2.2.2]oct[5]ene]-6'-carbonitrile; Spiro[2-oxabicyclo[2.2.2]oct-5-ene-3,2'-dihydrofuran]-6'-carbonitrile, 4-methylene-; (CAS 54852-61-8)
EINECS	Contact for details

Quality Control

Our production of this high-purity intermediate adheres to strict quality protocols to ensure batch-to-batch consistency and reliability for sensitive synthesis workflows. Quality is verified through a comprehensive suite of analytical techniques including HPLC, GC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) documenting identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to prevent decomposition. Keep away from incompatible materials such as strong bases and fluorides.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.