Description

n-(3-Methyl-1-Oxo-2-Butenyl)Glycine Trimethylsilyl Ester is a specialized organosilicon-protected amino acid derivative, serving as a crucial building block in advanced organic synthesis. Its primary value lies in its role as a protected glycine equivalent, enabling complex peptide coupling and medicinal chemistry research where standard amino acid reactivity must be controlled. This high-purity intermediate is essential for pharmaceutical R&D laboratories and fine chemical manufacturers focused on developing novel therapeutic compounds and bioactive molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel peptide-based drugs and protease inhibitors.
• Peptide Chemistry: Used as a protected glycine derivative in solid-phase and solution-phase peptide synthesis (SPPS).
• Medicinal Chemistry Research: Employed in the design and construction of complex molecular scaffolds for biological screening.
• Organosilicon Chemistry: Serves as a reagent in studies involving silicon-mediated protection and deprotection strategies.
• Bioconjugation: Potential use in creating stable linkages for antibody-drug conjugates (ADCs) or protein labeling.
• Chemical Biology Probes: Synthesis of activity-based probes or labeled analogs for studying enzyme function.

Basic Information

Product Name	n-(3-Methyl-1-Oxo-2-Butenyl)Glycine Trimethylsilyl Ester
CAS No.	54824-02-1
Molecular Formula	C10H19NO3Si
Molecular Weight	229.35 g/mol
Synonyms	Glycine, N-(3-methyl-1-oxo-2-butenyl)-, trimethylsilyl ester; 2-[(3-Methyl-1-oxo-2-buten-1-yl)amino]acetic acid trimethylsilyl ester; N-(3-Methyl-1-oxobut-2-en-1-yl)glycine trimethylsilyl ester; Trimethylsilyl N-(3-methyl-1-oxo-2-butenyl)glycinate; TMS ester of N-acetoacetyl glycine; Acetoacetyl-glycine TMS ester; N-Acetoacetyl-glycine trimethylsilyl ester
EINECS	Contact for details

Quality Control

Our n-(3-Methyl-1-Oxo-2-Butenyl)Glycine Trimethylsilyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and Karl Fischer titration for moisture content. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with the stringent requirements of research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be handled under a dry inert atmosphere (argon or nitrogen) to prevent decomposition. For long-term storage, consider storing under an inert gas blanket in a freezer (-20°C). Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.