Description

2,2,2-Tribromoethyl 5-Oxo-L-Prolinate is a specialized brominated proline derivative, serving as a crucial chiral building block and synthetic intermediate in advanced organic synthesis. Its value lies in its unique molecular architecture, which incorporates both a reactive tribromoethyl ester group and a pyrrolidinone ring system, enabling precise stereochemical control in complex molecule construction. This compound is essential for researchers and manufacturers in the pharmaceutical and fine chemical industries, particularly for the development of novel active pharmaceutical ingredients (APIs) and complex peptidomimetics.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new therapeutic agents, especially protease inhibitors and other enzyme-targeted drugs.
• Peptidomimetic Synthesis: Used to introduce constrained proline analogs into peptide chains to enhance metabolic stability and biological activity.
• Asymmetric Synthesis: Employed as a starting material or intermediate in catalytic asymmetric reactions to construct stereogenic centers with high enantiomeric purity.
• Chemical Biology Probes: Useful for the synthesis of labeled or modified amino acid derivatives used in mechanistic studies and target identification.
• Fine Chemical Production: Serves as a precursor for the manufacture of other high-value, specialized brominated organic compounds.
• Academic & Industrial R&D: A valuable reagent for methodological development in organic chemistry and medicinal chemistry research programs.

Basic Information

Product Name	2,2,2-Tribromoethyl 5-Oxo-L-Prolinate
CAS No.	54778-37-9
Molecular Formula	C7H8Br3NO3
Molecular Weight	409.86 g/mol
Synonyms	L-Pyroglutamic Acid 2,2,2-Tribromoethyl Ester; 5-Oxo-L-proline 2,2,2-tribromoethyl ester; (S)-5-Oxopyrrolidine-2-carboxylic acid 2,2,2-tribromoethyl ester; Tribromoethyl L-pyroglutamate; 2,2,2-Tribromoethyl (S)-5-oxopyrrolidine-2-carboxylate; 5-Oxo-L-proline tribromoethyl ester
EINECS	Contact for details

Quality Control

We maintain a stringent quality management system to ensure the identity, purity, and consistency of our chemical products. Every batch of 2,2,2-Tribromoethyl 5-Oxo-L-Prolinate is subjected to comprehensive analytical testing, including HPLC for purity and chiral integrity, NMR, and IR for structural confirmation. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all relevant specifications. Our quality commitment supports compliance with cGMP guidelines for pharmaceutical intermediates and meets the exacting standards of research and industrial applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (typically 15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided to prevent decomposition. Keep the container tightly sealed when not in use to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.