Description

n-Denitroso-N'-Nitroso Lomustine is a specialized nitrosourea derivative and a key intermediate in advanced pharmaceutical research and development. This compound is of significant interest for its role in the synthesis and study of novel alkylating agents with potential therapeutic applications. It is primarily utilized by research institutions and pharmaceutical companies engaged in oncology drug discovery and the development of targeted chemotherapeutic agents. The material is supplied to meet the stringent purity requirements of laboratory-scale synthesis and analytical reference standards.

Application

• Pharmaceutical Intermediate: A critical building block in the research-scale synthesis of novel nitrosourea-based chemotherapeutic agents and their analogs.
• Oncology Research: Used as a reference standard or active pharmaceutical ingredient (API) intermediate in preclinical studies targeting various cancer cell lines.
• Biochemical Research: Employed in studies investigating the mechanisms of DNA alkylation and cross-linking by nitrosourea compounds.
• Analytical Standard: Serves as a high-purity certified reference material (CRM) for quality control and method development in analytical laboratories.
• Process Chemistry: Utilized in route scouting and optimization for the development of scalable synthetic pathways to complex drug molecules.

Basic Information

Product Name	n-Denitroso-N'-Nitroso Lomustine
CAS No.	54749-91-6
Molecular Formula	C9H16ClN3O3
Molecular Weight	249.70 g/mol
Synonyms	1-(2-Chloroethyl)-3-(cyclohexyl)-1-nitrosourea (Denitroso Lomustine derivative); Lomustine Impurity; CCNU Derivative; 1-Nitroso-1-(2-chloroethyl)-3-cyclohexylurea; NSC 85441; Nitrosourea Research Compound; Cyclohexyl Chloroethyl Nitrosourea Analog
EINECS	Contact for details

Quality Control

Our n-Denitroso-N'-Nitroso Lomustine is manufactured under controlled conditions to ensure high purity and batch-to-batch consistency, suitable for demanding research applications. Each batch is subjected to rigorous analytical testing, including HPLC for purity determination and spectroscopic methods for structural confirmation. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.