Description

5'-(Ethylthio)-n-(Trimethylsilyl)-2'-O,3'-o-Bis(Trimethylsilyl)-5'-Deoxyadenosine CAS NO 54623-29-9 is a highly specialized, silyl-protected nucleoside derivative, a critical intermediate in advanced oligonucleotide synthesis. Its primary value lies in enabling precise chemical modifications for the development of novel therapeutic agents and diagnostic tools. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly those focused on antisense oligonucleotides, siRNA, and other nucleic acid-based therapeutics.

Application

• Key Intermediate in Oligonucleotide Synthesis: Used in the solid-phase and solution-phase synthesis of modified DNA/RNA strands, particularly for introducing thioether linkages at the 5'-position.
• Antisense Drug Development: Serves as a building block for creating nuclease-resistant oligonucleotides for therapeutic applications targeting genetic diseases.
• siRNA and miRNA Research: Facilitates the production of stabilized small interfering RNA (siRNA) and microRNA (miRNA) analogs with enhanced pharmacokinetic properties.
• Diagnostic Probe Manufacture: Employed in synthesizing labeled nucleic acid probes for advanced diagnostic assays and genomic research.
• Medicinal Chemistry & SAR Studies: Provides a platform for structure-activity relationship (SAR) studies by allowing specific modifications to the adenosine scaffold.
• Process Development for API Synthesis: Acts as a critical raw material in the scalable production of active pharmaceutical ingredients (APIs) for nucleic acid therapies.

Basic Information

Product Name	5'-(Ethylthio)-n-(Trimethylsilyl)-2'-O,3'-o-Bis(Trimethylsilyl)-5'-Deoxyadenosine
CAS No.	54623-29-9
Molecular Formula	C23H47N5O3SSi3
Molecular Weight	557.96 g/mol
Synonyms	5'-Deoxy-5'-(ethylthio)-N-(trimethylsilyl)-2',3'-bis-O-(trimethylsilyl)adenosine; 5'-(Ethylthio)-5'-deoxy-N-(trimethylsilyl)-2',3'-bis-O-(trimethylsilyl)adenosine; Silylated 5'-Ethylthioadenosine Derivative; 5'-S-Ethyl-5'-thio-2',3'-bis-O-(trimethylsilyl)-N-(trimethylsilyl)adenosine; Protected 5'-Thioether Adenosine; N,2',3'-Tris(trimethylsilyl)-5'-(ethylthio)-5'-deoxyadenosine
EINECS	Contact for details

Quality Control

Our production of this high-value intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for critical research and cGMP manufacturing. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry to confirm identity, purity, and stability. Certificates of Analysis (COA) detailing all relevant specifications are provided with every shipment. We support development and commercial projects requiring compliance with ICH guidelines for impurity profiling and control.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) in a dry, freezer. This compound is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.