Description

5'-(Methylthio)-n-(Trimethylsilyl)-2'-O,3'-o-Bis(Trimethylsilyl)-5'-Deoxyadenosine CAS NO 54623-28-8 is a highly specialized, multi-protected nucleoside derivative, serving as a critical synthetic intermediate in advanced organic and medicinal chemistry. Its value lies in providing a protected scaffold that allows for selective chemical modifications at specific sites on the adenosine molecule, which is essential for constructing complex oligonucleotides and nucleotide analogs. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, antisense oligonucleotides, and sophisticated biochemical probes.

Application

• Oligonucleotide Synthesis: As a key protected building block in the solid-phase or solution-phase synthesis of modified DNA/RNA strands.
• Antisense Drug Development: For the research and production of antisense oligonucleotides targeting specific genes for therapeutic applications.
• Nucleotide Analog Synthesis: Serving as a precursor for creating novel nucleoside triphosphate analogs used as enzyme inhibitors or diagnostic tools.
• Medicinal Chemistry Research: Utilized in structure-activity relationship (SAR) studies to develop new antiviral or anticancer agents.
• Bioconjugation: The protected functional groups allow for controlled attachment of fluorophores, affinity tags, or other molecules for probe development.
• Process Chemistry: Used in the scale-up and optimization of synthetic routes for nucleotide-based active pharmaceutical ingredients (APIs).

Basic Information

Product Name	5'-(Methylthio)-n-(Trimethylsilyl)-2'-O,3'-o-Bis(Trimethylsilyl)-5'-Deoxyadenosine
CAS No.	54623-28-8
Molecular Formula	C22H43N5O3SSi3
Molecular Weight	529.93 g/mol
Synonyms	5'-Deoxy-5'-(methylthio)-N-(trimethylsilyl)-2',3'-O-bis(trimethylsilyl)adenosine; 5'-S-Methyl-5'-thio-N-(trimethylsilyl)-2',3'-O-bis(trimethylsilyl)adenosine; 5'-(Methylthio)-5'-deoxy-N-(trimethylsilyl)-2',3'-O-bis(trimethylsilyl)adenosine; Protected 5'-Methylthioadenosine Derivative; Silylated 5'-Deoxy-5'-(methylthio)adenosine; MT-TMS-Adenosine Derivative
EINECS	Contact for details

Quality Control

Our production of this high-purity synthetic intermediate adheres to stringent quality protocols. Every batch undergoes comprehensive analytical characterization, including HPLC for purity assessment, NMR (1H & 13C) for structural confirmation, and mass spectrometry for identity verification. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with your research or cGMP starting material requirements. Specifications can be customized to meet specific project needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below. This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon or nitrogen) when opening the container to prevent degradation. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.