Description

8-Amino-1,4-dioxaspiro[4.5]decane-8-carbonitrile is a versatile spirocyclic nitrile building block of significant interest in advanced organic synthesis. Its unique structure, featuring both a protected ketone and a reactive amino-nitrile moiety, makes it a critical intermediate for constructing complex molecular architectures. This compound is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of spirocyclic drug candidates, including potential central nervous system (CNS) agents and enzyme inhibitors.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides with complex spirocyclic backbones.
• Fine Chemical Production: Serves as a precursor for specialty chemicals, dyes, and advanced materials requiring its specific stereochemistry.
• Academic & Contract Research: Essential reagent in university and CRO laboratories for methodology development and exploring new chemical spaces in heterocyclic chemistry.
• Peptidomimetics: Utilized in the design and synthesis of conformationally restricted peptide analogs for biological studies.
• Ligand and Catalyst Development: Acts as a starting material for creating novel chiral ligands and organocatalysts used in asymmetric synthesis.

Basic Information

Product Name	8-Amino-1,4-dioxaspiro[4.5]decane-8-carbonitrile
CAS No.	54621-16-8
Molecular Formula	C9H14N2O2
Molecular Weight	182.22 g/mol
Synonyms	8-Amino-1,4-dioxaspiro[4.5]decane-8-carbononitrile; 8-Cyano-8-amino-1,4-dioxaspiro[4.5]decane; 8-Amino-8-cyano-1,4-dioxaspiro[4.5]decane; 1,4-Dioxaspiro[4.5]decane-8-carbonitrile, 8-amino-; 8-Amino-1,4-dioxaspiro[4,5]decan-8-carbonitrile; 8-Amino-8-cyanospiro[4.5]decane-1,4-dione ketal; 8-Amino-8-cyano-1,4-dioxaspiro[4.5]decane
EINECS	Contact for details

Quality Control

Our 8-Amino-1,4-dioxaspiro[4.5]decane-8-carbonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support custom synthesis and can tailor purity grades to meet specific research or GMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.