Description

[(4,4-Dimethyl-5α-Androstan-3β-Yl)Oxy]Trimethylsilane is a high-purity, organosilicon-protected steroid derivative, primarily used as a critical synthetic intermediate in advanced pharmaceutical research and development. Its core value lies in enabling precise chemical modifications to the steroid backbone, which is essential for creating novel therapeutic agents and conducting metabolic studies. This compound is particularly needed by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries working on hormone-related therapies, anti-inflammatory agents, and other steroidal compounds.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of novel steroid-based active pharmaceutical ingredients (APIs).
• Research Chemical: Used in academic and industrial laboratories for studying steroid metabolism, receptor binding, and structure-activity relationships (SAR).
• Process Chemistry: Employed in the development and scale-up of synthetic routes for complex steroidal molecules, leveraging the trimethylsilyl (TMS) protecting group.
• Reference Standard: Serves as a certified reference material (CRM) for analytical method development and quality control in steroid manufacturing.
• Bioconjugate Chemistry: Potential use in creating steroidal probes or conjugates for diagnostic and targeted drug delivery applications.

Basic Information

Product Name	[(4,4-Dimethyl-5α-Androstan-3β-Yl)Oxy]Trimethylsilane
CAS No.	54412-05-4
Molecular Formula	C₂₄H₄₂O₂Si
Molecular Weight	390.68 g/mol
Synonyms	3β-[(Trimethylsilyl)oxy]-4,4-dimethyl-5α-androstane; 4,4-Dimethyl-5α-androstan-3β-ol trimethylsilyl ether; 3β-Trimethylsiloxy-4,4-dimethyl-5α-androstane; 4,4-Dimethylandrostan-3β-yloxytrimethylsilane; Androstane-3β-ol, 4,4-dimethyl-, 3-(trimethylsilyl) ether, (5α)-; Trimethyl(4,4-dimethyl-5α-androstan-3β-yloxy)silane
EINECS	Contact for details

Quality Control

Our [(4,4-Dimethyl-5α-Androstan-3β-Yl)Oxy]Trimethylsilane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting compliance with cGMP and ISO standards for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.