Description

1-o-Oleoyl-2-O,3-o-Bis(Trimethylsilyl)Glycerol is a specialized, high-purity chemical intermediate featuring a glycerol backbone that is selectively protected and functionalized. This compound is critical for synthetic chemists requiring precise control over reaction pathways in complex organic synthesis, particularly in the construction of phospholipids and other lipid analogs. It is primarily utilized by research institutions and pharmaceutical development teams working on advanced drug delivery systems, prodrug synthesis, and lipid-based nanotechnology.

Application

• Lipid and Phospholipid Synthesis: A key protected intermediate for the controlled, stepwise synthesis of complex phospholipids and glycolipids.
• Prodrug Development: Used to create lipophilic prodrugs, enhancing the bioavailability and targeted delivery of active pharmaceutical ingredients (APIs).
• Lipid Nanoparticle (LNP) Research: Serves as a building block in the design and formulation of novel lipid components for mRNA and siRNA delivery systems.
• Chemical Derivatization: Employed in analytical chemistry to derivative sensitive compounds for Gas Chromatography (GC) or Mass Spectrometry (MS) analysis.
• Surface Modification Agent: Used to introduce hydrophobic, silyl-protected groups onto material surfaces or biomolecules.
• Academic & Industrial R&D: A valuable tool for exploratory research in medicinal chemistry, chemical biology, and material science.

Basic Information

Product Name	1-o-Oleoyl-2-O,3-o-Bis(Trimethylsilyl)Glycerol
CAS No.	54284-47-8
Molecular Formula	C30H62O4Si2
Molecular Weight	543.0 g/mol
Synonyms	1-Oleoyl-2-hydroxy-3-O,O-bis(trimethylsilyl)-sn-glycerol; 1-Oleoyl-2,3-O,O-bis(trimethylsilyl)glycerol; Glycerol, 1-oleoyl-2,3-O,O-bis(trimethylsilyl)-; 2,3-O,O-Bis(trimethylsilyl)-1-oleoylglycerol; sn-Glycerol 1-oleate 2,3-bis(trimethylsilyl) ether; TMS-protected monoolein; 1-Monoolein 2,3-bis(trimethylsilyl) ether
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for research and development. Each batch is characterized using advanced analytical techniques including NMR, HPLC, and GC to confirm identity, purity, and stability. Certificates of Analysis (COA) detailing all relevant specifications are available upon request. We adhere to a strict quality management system to guarantee batch-to-batch consistency for your critical synthetic work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to prevent degradation. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.