Description

1-Methoxy-3-Trimethylsiloxy-1,3-Butadiene is a versatile and highly reactive silyl enol ether derivative, serving as a critical building block in advanced organic synthesis. Its primary value lies in its ability to act as a masked 1,3-dicarbonyl equivalent, enabling efficient and selective carbon-carbon bond formation under mild conditions. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and specialty chemical industries, facilitating the synthesis of complex molecules, heterocycles, and fine chemicals.

Application

• Pharmaceutical Intermediates: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for constructing complex heterocyclic scaffolds and side chains.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and plant growth regulators requiring specific ketone or aldehyde functionalities.
• Fine Chemical Manufacturing: Employed as a versatile reagent for the production of flavors, fragrances, and performance chemicals.
• Polymer Chemistry: Acts as a monomer or modifying agent in the development of specialty polymers with tailored properties.
• Academic & Industrial R&D: A fundamental reagent for methodological development in organic chemistry, including annulation and cycloaddition reactions.
• Material Science: Used in the surface modification of materials and the synthesis of organic-inorganic hybrid compounds.

Basic Information

Product Name	1-Methoxy-3-Trimethylsiloxy-1,3-Butadiene
CAS No.	54125-02-9
Molecular Formula	C8H16O2Si
Molecular Weight	172.30 g/mol
Synonyms	1-Methoxy-3-(trimethylsilyloxy)-1,3-butadiene; Danishefsky's Diene; (1-Methoxy-3-trimethylsiloxy-1,3-butadiene); trans-1-Methoxy-3-trimethylsiloxy-1,3-butadiene; 1-Methoxy-3-(trimethylsiloxy)-1,3-butadiene; 1,3-Butadiene, 1-methoxy-3-(trimethylsilyloxy)-; 3-Trimethylsiloxy-1-methoxy-1,3-butadiene
EINECS	Contact for details

Quality Control

Our 1-Methoxy-3-Trimethylsiloxy-1,3-Butadiene is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including chromatography (GC/HPLC) and spectroscopic analysis (NMR, IR), to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing identity, assay, and impurity profiles are available upon request. We adhere to cGMP principles where applicable to support our customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.