Description

8-Chloro-5,6-Dihydro-4-Methyl-1-Phenyl-4H-[1,2,4]Triazolo[4,3-A][1,5]Benzodiazepine is a high-purity, complex heterocyclic compound of significant interest in advanced organic synthesis. This molecule serves as a critical pharmacological intermediate and a versatile building block for the development of novel active pharmaceutical ingredients (APIs). It is primarily sought by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of specialized benzodiazepine analogs and other bioactive molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the research and development of novel therapeutic agents, particularly in central nervous system (CNS) drug discovery.
• Active Pharmaceutical Ingredient (API) Synthesis: Used as a core scaffold for constructing complex molecules with potential anxiolytic, sedative, or other pharmacological properties.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to explore and optimize biological activity profiles.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Fine Chemical Synthesis: Utilized as a specialized building block in multi-step organic syntheses for creating complex heterocyclic compounds.
• Biochemical Research: Applied in studies investigating ligand-receptor interactions, particularly with GABAA and related receptors.

Basic Information

Product Name	8-Chloro-5,6-Dihydro-4-Methyl-1-Phenyl-4H-[1,2,4]Triazolo[4,3-A][1,5]Benzodiazepine
CAS No.	54028-89-6
Molecular Formula	C18H15ClN4
Molecular Weight	322.79 g/mol
Synonyms	8-Chloro-5,6-dihydro-4-methyl-1-phenyl-4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepine; 8-Chloro-4-methyl-1-phenyl-4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepine; 54028-89-6; Lopirazepam (unapproved drug candidate); 4H-[1,2,4]Triazolo[4,3-a][1,5]benzodiazepine, 8-chloro-5,6-dihydro-4-methyl-1-phenyl-; Triazolobenzodiazepine derivative
EINECS	Contact for details

Quality Control

Our 8-Chloro-5,6-Dihydro-4-Methyl-1-Phenyl-4H-[1,2,4]Triazolo[4,3-A][1,5]Benzodiazepine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) that confirm compliance with customer specifications and relevant industry standards for research-grade materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.