Description

2-Isocyano-(Indol-3-Yl)-Acetic Acid Methyl Ester is a specialized heterocyclic building block of significant interest in advanced organic synthesis. This compound matters for its unique bifunctional structure, incorporating both a reactive isocyano group and an indole moiety, enabling the construction of complex molecular architectures. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel bioactive molecules and chemical libraries.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel indole-based drug candidates, including potential kinase inhibitors and GPCR modulators.
• Agrochemical Research: Used in the development of new plant growth regulators or pesticides with indole scaffolds.
• Chemical Biology & Probe Development: Serves as a versatile building block for creating activity-based probes and molecular tools to study biological systems.
• Multicomponent Reaction (MCR) Chemistry: Exploited in Passerini- and Ugi-type reactions to efficiently generate diverse heterocyclic compound libraries.
• Material Science Precursor: Potential starting material for synthesizing functional organic molecules with optoelectronic properties.
• Academic & Contract Research: Essential for methodological development and exploration of new synthetic pathways in university and CRO laboratories.

Basic Information

Product Name	2-Isocyano-(Indol-3-Yl)-Acetic Acid Methyl Ester
CAS No.	53941-27-8
Molecular Formula	C₁₂H₁₀N₂O₂
Molecular Weight	214.22 g/mol
Synonyms	Methyl 2-isocyano-2-(1H-indol-3-yl)acetate; 2-(1H-Indol-3-yl)-2-isocyanoacetic acid methyl ester; 2-Isocyano-2-(indol-3-yl)acetic acid methyl ester; 3-Indolyl(isocyano)acetic acid methyl ester; Methyl (isocyano)(1H-indol-3-yl)acetate; (1H-Indol-3-yl)(isocyano)acetic acid methyl ester
EINECS	Contact for details

Quality Control

Our 2-Isocyano-(Indol-3-Yl)-Acetic Acid Methyl Ester is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and FTIR, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container sealed under an inert atmosphere if possible to maximize shelf-life stability. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.